Gonioscopes

ABSTRACT

Gonioscope devices are disclosed herein that are configured to enable a medical professional to view structure inside the eye that is ordinarily hidden from normal view. The gonioscope can be an integrally molded single piece that includes both a handle and a gonioscopic optical element. The proximal surface can have a viewing area and a light diffusing area. A recess can provide access to a wound site on the eye while the gonioscope is used for viewing. The handle can be configured to encourage proper alignment of the gonioscope with the eye. The gonioscope can provide an optical fixation point for the subject to focus on to facilitate proper alignment of the eye. The gonioscope can have one or more retention elements configured to engage the tissue of the eye around the contact surface to stabilize the gonioscope. The gonioscope can couple to a lid speculum.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the benefit under 35 U.S.C. § 119(e) of U.S.Provisional Patent Application No. 62/463,523, filed Feb. 24, 2017, andtitled GONIOSCOPES. The entirety contents of the above-identifiedapplication is hereby incorporated by reference herein and made part ofthis specification for all that it discloses.

INCORPORATION BY REFERENCE

U.S. Pat. No. 8,070,290, issued Dec. 6, 2011, and titled GONIOSCOPE FORIMPROVED VIEWING, is hereby incorporated by reference in its entirety.U.S. Patent Application Publication No. 2012/0257167, published Oct. 11,2012, and titled GONIOSCOPE FOR IMPROVED VIEWING, is hereby incorporatedby reference in its entirety. PCT Patent Application Publication No. WO2016/154066, published Sep. 29, 2016, and titled GONIOSCOPIC DEVICES, ishereby incorporated by reference in its entirety.

BACKGROUND Field of the Disclosure

Various embodiments disclosed herein relate to ophthalmoscopic devices,systems and methods useful for viewing structures including but notlimited to the anterior chamber, trabecular meshwork, iris root, scleralspur, and/or related nearby anatomical structures in the eye. Variousembodiments described herein may be useful for ophthalmologic diagnoses,treatments, monitoring, and/or surgical procedures.

Description of the Related Art

Gonioscopy is a technique used for viewing the inner parts of the eye,such as the retina and the anterior chamber angle of the eye forevaluation, management, and classification of normal and abnormalstructures. Devices used for gonioscopy are known as gonioscopes.Observation of the anterior chamber and especially its angle areas,which are difficult or impossible to see with the use of simplemicroscopes, can be used for diagnosis of eye diseases. For example, theclassification of glaucoma can rely heavily upon knowledge of theanterior segment anatomy, particularly that of the anterior chamberangle. Additionally, some surgical procedures used to treat glaucomainvolve placing a small tubular stent into the trabecular meshwork inthe anterior chamber angle formed by the iris and the cornea. Properplacement of the stent may depend on visualization of the Trabeculum andthe angle.

The anterior chamber of a human eye can be evaluated with an illuminatedmicroscope (e.g., slit lamp stereomicroscopy), but the chamber angle istypically hidden from ordinary view because of total internal reflectionof light rays emanating from the angle structures. A small opticaldevice known to ophthalmologists as a gonioscope can be used to enhancevisibility of the Trabeculum and the angle. During surgicalapplications, it may be hand held by the surgeon in place over thepatient's cornea while he/she is performing the surgical procedure.

SUMMARY

Certain example embodiments are summarized below for illustrativepurposes. The embodiments are not limited to the specificimplementations recited herein. Embodiments may include several novelfeatures, no single one of which is solely responsible for its desirableattributes or which is essential to the embodiments.

Various embodiments disclosed herein can relate to a gonioscope that caninclude a gonioscopic optical element made of transparent material. Thegonioscopic optical element can include a distal contact surface that isconcave and configured to contact a surface of an eye of a subject, anda proximal surface. The gonioscopic optical element can be configured toreceive light from structure inside the eye through the distal contactsurface and to output the light through the proximal surface to form animage of the structure inside the eye. The gonioscope can include ahandle coupled to the gonioscopic optical element.

In some embodiments, the handle and the gonioscopic optical element canbe integrally formed of the same material. The gonioscope can be adisposable item. The gonioscope can be a single-use item.

In some embodiments, the proximal surface can include a viewing portionthat can be configured to output the light to form the image of thestructure inside the eye, and a light diffusing portion that can beconfigured to diffuse light that passes through the light diffusingportion. The light diffusing portion can include surface diffusingfeatures. The light diffusing portion can include embedded diffusingfeatures.

In some embodiments, the gonioscopic optical element is configured toform the image with magnification that is less than 1.3×. In someembodiments, the gonioscopic optical element is configured to form theimage with magnification that is less than 1.2×. In some embodiments,the gonioscopic optical element can include an anti-reflection coating.

In some embodiments, the gonioscopic optical element can include acurved distal contact surface, a curved proximal surface, and a recessat a front side of the gonioscope formed by an intersection of thecurved distal surface and the curved proximal surface. The recess canhave a width greater than 7 mm. The recess can have a width greater than10 mm. The width of the recess can be less than 15 mm.

In some embodiments, the handle can have an elliptical cross-sectionalshape with a major axis that is longer than a minor axis. In someembodiments, the handle can be configured to receive light and topropagate the light (e.g., by total internal reflection) to thegonioscopic optical element to input the light into the eye. The handlecan be coupled to the gonioscopic optical element at a joint locationthat is configured to direct light from the handle into the gonioscopicoptical element to provide an optical fixation point for the subject.The handle can include one or more light entry areas configured to inputlight into the handle. In some embodiments, the gonioscope can includean ambidextrous handle coupled to the gonioscopic optical element, andthe ambidextrous handle can extend upward along a center plane thatdivides the gonioscopic optical element into a right side and a leftside. The gonioscope and/or the gonioscopic optical element can besymmetrical across the center plane. In some embodiments, the handle canbe omitted. In some embodiments, the gonioscope can include a handlecoupled to the gonioscopic optical element at a joint location thatextends across a width that is at least 50% of the width of thegonioscopic optical element.

In some embodiments, the gonioscope can include a right wing extendingfrom a right side of the gonioscopic optical element and configured toattach to a right-side eye engagement piece of a lid speculum, and aleft wing extending from a left side of the gonioscopic optical elementand configured to attach to a left-side eye engagement piece of a lidspeculum. The right wing can include a hole configured to receive aright post on the lid speculum, and the left wing can include a holethat is configured to receive a left post on the lid speculum.

In some embodiments, the gonioscopic optical element can be configuredto receive light from a target structure inside the eye through thedistal contact surface and to output the light through the proximalsurface to provide an image to a microscope of the target structureinside the eye. The target structure inside the eye can be positioned ata center portion of the image produced by the gonioscopic opticalelement. The gonioscopic optical element can be configured to receiveillumination light from a microscope through the proximal surface and tooutput the illumination light through the distal surface into eye, suchthat the target structure receives more of the illumination light thanother structures in the eye.

In some embodiments, the gonioscope can weigh less than 3 grams. In someembodiments, the gonioscope can weigh less than 2 grams. In someembodiments, the gonioscope can weigh at least 1 gram. In someembodiments, the distal surface has a radius of curvature of 8 mm to 12mm.

In some embodiments, the gonioscope includes one or more retentionelements configured to engage tissue of the eye to retain the gonioscopein position on the eye. The one or more retention elements can bepositioned on one or more arms that extend from the gonioscopic opticalelement.

Various embodiments disclosed herein can relate to a gonioscope that caninclude a gonioscopic optical element having a first portion and asecond portion. The first portion can include a first distal contactsurface that is concave and configured to contact a surface of an eye ofa subject at a first location, a first reflection surface, and a secondreflection surface. The first portion of the gonioscopic optical elementcan be configured to receive light from structure inside the eye throughthe first distal contact surface, to reflect the light from the firstreflection surface, to reflect the light from the second reflectionsurface, and to output the light from the gonioscope to form an image ofthe structure inside the eye. The second portion can include a seconddistal contact surface that is concave and configured to contact thesurface of the eye at a second location that is spaced apart from thefirst location. The second portion of the gonioscopic optical elementcan be configured to receive light from outside the gonioscope and todirect the light through the second distal contact surface to illuminatethe structure in the eye.

Various embodiments disclosed herein can relate to a gonioscope that caninclude a gonioscopic optical element having a first portion and asecond portion. The first portion can include a first distal contactsurface that is concave and configured to contact a surface of an eye ofa subject at a first location. The second portion can include a seconddistal contact surface that is concave and configured to contact thesurface of the eye at a second location that is spaced apart from thefirst location.

The gonioscope can include a handle, in some embodiments. The handle caninclude an annular gripping portion positioned around an upper portionof the gonioscopic optical element.

In some embodiments, the gonioscopic optical element can include aproximal surface that extends over both the first portion and the secondportion of the gonioscopic optical element.

In some embodiments, the second distal contact portion can be configuredto be positioned over the structure of the eye that is being imaged. Insome embodiments, the second portion of the gonioscopic optical elementcan be configured to direct light into the eye without reflecting thelight.

In some embodiments, the gonioscope can be configured to block lightfrom outside the gonioscope from entering the eye along the optical axisor along the visual axis of the eye. In some embodiments, the secondreflection surface can be configured to be positioned directly above acenter of the cornea of the eye. In some embodiments, the firstreflection surface can include a reflective material. In someembodiments, the second reflection surface can include a reflectivematerial. The reflective material can include a metal coating.

In some embodiments, the gonioscope can include an optical fixationpoint light redirection element that is configured to redirect light toprovide an optical fixation point viewable by the subject. The lightredirection element can include an optical fixation point reflectionsurface. The optical fixation point light redirection element can beconfigured to redirect the light toward the outside of the secondreflection surface, and the outside of the second reflection surface canbe configured to reflect the light into the eye so that the light isvisible to the subject to provide the optical fixation point. In someembodiments, the second portion of the gonioscopic optical element caninclude a surface that has a reflective material with an aperture formedin the reflective material, and the aperture can be configured to enablelight redirected by the optical fixation point redirection element topass through the surface.

Various embodiments can relate to a gonioscope that includes agonioscopic optical element made of transparent material and having adistal contact surface that is concave and configured to contact asurface of an eye of a subject, and a proximal surface. The gonioscopicoptical element can be configured to receive light from structure insidethe eye through the distal contact surface and to output the lightthrough the proximal surface to form an image of the structure insidethe eye. The proximal surface can be convex along a first direction. Theproximal surface can be concave along a second direction. The gonioscopecan optionally include a handle coupled to the gonioscopic opticalelement.

The second direction can be orthogonal to the first direction. The imagecan have magnification along a first direction of the image thatcorresponds to the first direction of the proximal surface. The imagecan have demagnification along a second direction of the image thatcorresponds to the second direction of the proximal surface. The imagecan have magnification along a first direction and demagnification alonga second direction. The magnification can be between about 1.1× andabout 1.5×. The magnification can be between about 1.2× and about 1.4×.The demagnification can be between about 0.95× and about 0.75×. Thedemagnification can be between about 0.9× and about 0.8×.

Various embodiments can relate to a gonioscope that includes agonioscopic optical element made of transparent material and having adistal contact surface that is concave and configured to contact asurface of an eye of a subject and a proximal surface. The gonioscopicoptical element can be configured to receive light from structure insidethe eye through the distal contact surface and to output the lightthrough the proximal surface to form an image of the structure insidethe eye. A light entry area can be configured to receive opticalfixation light into the gonioscopic optical element. The gonioscopicoptical element can include a recess having a base surface configured toredirect the optical fixation light into the eye of the subject toproduce an optical fixation feature visible to the subject. Thegonioscope can optionally include a handle coupled to the gonioscopicoptical element.

The gonioscopic optical element can include a protrusion on a frontside, and a surface of the protrusion can include the light entry area.The light entry area can include a curved surface. The light entry areacan have optical power. The light entry area can be configured to focusthe optical fixation light onto the base surface. The light entry areacan be configured to collimate the optical fixation light and to directthe collimated optical fixation light to the base surface. The lightentry area can be configured to distribute the optical fixation lightacross the base surface. The base surface can be configured to reflectthe optical fixation light by total internal reflection. The basesurface can be configured to scatter the optical fixation light. Thebase surface can have a first area configured to direct a first amountof the optical fixation light into the eye to produce a first portion ofthe optical fixation feature visible to the subject, and a second areaconfigured to direct a second amount of the optical fixation light intothe eye to produce a second portion of the optical fixation featurevisible to the subject. The first portion can be visible distinct fromthe second portion. The first portion can be brighter than the secondportion.

Various embodiments can relate to a gonioscope that includes agonioscopic optical element made of transparent material having a distalcontact surface that is concave and configured to contact a surface ofan eye of a subject, and a proximal surface. The gonioscopic opticalelement can be configured to receive light from structure inside the eyethrough the distal contact surface and to output the light through theproximal surface to form an image of the structure inside the eye. Thegonioscope can include markings that are visible in the image. Thegonioscope can optionally include a handle coupled to the gonioscopicoptical element.

The markings can be on the distal contact surface and/or on the proximalsurface and/or embedded in the gonioscopic optical element. The markingscan divide the image into a plurality of areas. The markings can includea plurality of lines. The markings can include a plurality of areashaving different light transmission properties. The markings can includea plurality of areas having different colors. The markings can designateangle increments in the image.

Various embodiments can relate to a gonioscopic system that includes agonioscope having a gonioscopic optical element made of transparentmaterial and including a distal contact surface that is concave andconfigured to contact a surface of an eye of a subject, and a proximalsurface. The gonioscopic optical element can be configured to receivelight from structure inside the eye through the distal contact surfaceand to output the light through the proximal surface to form an image ofthe structure inside the eye. The gonioscope can optionally include ahandle. The system can include a support having an engagement elementconfigured to attach the support to the gonioscope and an eye engagementfeature configured to engage between the eye and an anatomical structureadjacent the eye to support the gonioscope.

The engagement element can include a handle attachment configured toattach to the handle of the gonioscope. The handle attachment caninclude a through hole configured to receive the handle therethrough.The gonioscope can include at least one arm extending from thegonioscopic optical element, and the engagement element can include anarm attachment configured to attach to the arm. The arm attachment caninclude a recess configured to receive the arm therein. The gonioscopecan include a recess, and the engagement element can include aprotrusion configured to be received into the recess of the gonioscope.The eye engagement feature can include at least one flap configured tofit between the eye and an eyelid. The eye engagement feature can have afirst flap configured to fit between the eye and an upper eyelid and asecond flap configured to fit between the eye and a lower eyelid. Theeye engagement feature can include at least one flap configured toengage a corner of the eye.

BRIEF DESCRIPTION OF THE DRAWINGS

Certain embodiments will be discussed in detail with reference to thefollowing figures, wherein like reference numerals refer to similarfeatures throughout. These figures are provided for illustrativepurposes and the embodiments are not limited to the specificimplementations illustrated in the figures.

FIG. 1 is a top-front perspective view of an example embodiment of agonioscope.

FIG. 2 is a bottom-rear perspective view of the example embodiment of agonioscope.

FIG. 3 is a cross-sectional view taken through a center of an examplegonioscopic optical element.

FIG. 4 shows a cross-sectional view of an example gonioscopic opticalelement positioned on the cornea of an eye.

FIG. 5 shows a partial front view of an example embodiment of agonioscope.

FIG. 6 shows a bottom-rear partial perspective view of an exampleembodiment of a gonioscope.

FIG. 7 shows a front partial view of an example embodiment of agonioscope imaging a medical device inside an eye.

FIGS. 8-10 show front partial views of another gonioscope imaging amedical device inside an eye.

FIG. 11 shows a front view of an example embodiment of a gonioscopicoptical element imaging a field of view.

FIG. 12 shows a front view of another gonioscope optical element imaginga different field of view.

FIG. 13 shows an example embodiment of a gonioscope positioned on an eyeand supported by a hand.

FIG. 14 shows the handle of an example embodiment of a gonioscope beingheld.

FIG. 15 shows a side view of an example embodiment of a gonioscope.

FIG. 16 shows a front view of an example embodiment of a gonioscope.

FIG. 17 shows a top view of an example embodiment of a gonioscope.

FIG. 18 shows a cross-sectional view of an example embodiment of agonioscope taken through the handle.

FIG. 19 shows a partial-cross sectional view of an example embodiment ofa gonioscope that includes a light guide for providing an opticalfixation point.

FIG. 20 shows another example embodiment of a gonioscope that includes alight guide for providing an optical fixation point.

FIG. 21 is a top-front perspective view of an example embodiment of agonioscope.

FIG. 22 is a bottom-rear perspective view of the example embodiment of agonioscope.

FIG. 23 is a front view of an example embodiment of a gonioscope.

FIG. 24 is a cross-sectional view of an example embodiment of agonioscope.

FIG. 25 shows an example embodiment of a gonioscope and a lid speculum.

FIG. 26 shows an example embodiment of a gonioscope attached to a lidspeculum.

FIG. 27 shows a top-front perspective view of an example embodiment of agonioscope.

FIG. 28 shows a bottom-rear perspective view of an example embodiment ofa gonioscope.

FIG. 29 is a top-down view of an example embodiment of a gonioscope,where the proximal surface is shown transparent to illustrate thesurfaces inside the gonioscope.

FIG. 30 is a perspective, cross-sectional view of an example embodimentof a gonioscope.

FIG. 31 is a cross-sectional view of an example embodiment of agonioscope positioned on an eye.

FIG. 32 is a cross-sectional view of an example embodiment of agonioscope.

FIG. 33 is a top-down view of an example embodiment of a gonioscope,where the proximal surface is shown transparent to illustrate thesurfaces inside the gonioscope.

FIG. 34 is a top-front perspective view of an example embodiment of agonioscope.

FIG. 35 is a top-rear perspective view of an example embodiment of agonioscope.

FIG. 36 is a bottom-front perspective view of an example embodiment of agonioscope.

FIG. 37 is a cross-sectional perspective view of the example embodimentof a gonioscope taken at line 37-37 shown in FIG. 36.

FIG. 38 is a cross-section view of the example embodiment of agonioscope taken at line 38-38 shown in FIG. 36.

FIG. 39 is a cross-section view of an example embodiment of agonioscope.

FIG. 40A is a cross-section view of an example embodiment of agonioscope.

FIG. 40B is a cross-section view of an example embodiment of agonioscope.

FIG. 40C is a cross-section view of an example embodiment of agonioscope.

FIG. 41 is a cross-section view of an example embodiment of agonioscope.

FIG. 42 is a cross-section view of an example embodiment of agonioscope.

FIG. 43 is a cross-section view of an example embodiment of agonioscope.

FIG. 44 shows an example embodiment of a surface for producing anoptical fixation feature.

FIG. 45 shows an example embodiment of a surface for producing anoptical fixation feature.

FIG. 46 shows an example embodiment of a surface for producing anoptical fixation feature.

FIG. 47 shows an example embodiment of a surface for producing anoptical fixation feature.

FIG. 48 shows an example embodiment of a gonioscope having markings.

FIG. 49 shows another example embodiment of a gonioscope havingmarkings.

FIG. 50 shows an image resulting from the markings similar to FIG. 48.

FIG. 51 shows an image resulting from the markings similar to FIG. 49.

FIG. 51A shows another example of a gonioscope having marking.

FIG. 51B shows an image resulting from the markings similar to FIG. 51A.

FIG. 51C shows another example of a gonioscope having markings.

FIG. 52 is a bottom-front perspective view of an example embodiment of asupport being used with a gonioscope.

FIG. 53 is a top-rear perspective view of an example embodiment of asupport being used with a gonioscope.

FIG. 54 is a bottom-front perspective view of an example embodiment of asupport being used with a gonioscope.

FIG. 55 is a top-rear perspective view of an example embodiment of asupport being used with a gonioscope.

FIG. 56 is a bottom-front perspective view of an example embodiment of asupport being used with a gonioscope.

FIG. 57 is a top-rear perspective view of an example embodiment of asupport being used with a gonioscope.

FIG. 58 is a side view of an example embodiment of a support for usewith a gonioscope.

FIG. 59 is a top-rear perspective view of an example embodiment of asupport being used with a gonioscope.

FIG. 59A is a perspective view of an example embodiment of a support foruse with a gonioscope.

FIG. 59B is a bottom-front perspective view of the support coupled to agonioscope.

FIG. 59C is a top-rear perspective view of the support coupled to thegonioscope.

FIG. 59D is a bottom-front perspective view of another exampleembodiment of a support, shown coupled to a gonioscope.

FIG. 59E is a top-rear perspective few of the support coupled to thegonioscope.

FIGS. 60A and 60B are schematic side views of different exampleembodiments of a gonioscopic optical element having at least onefixation point.

FIG. 60C is a schematic drawing of different example embodiments ofmultiple gonioscopic fixation points.

FIG. 60D is a schematic drawing of side views of different exampleembodiments of gonioscopic optical elements that include light pipes.

FIG. 60E is a schematic drawing of bottom views of different exampleembodiments of gonioscopic optical elements that include light pipes.

FIG. 60F is a schematic drawing of a side view of an example embodimentof a gonioscopic optical element.

DETAILED DESCRIPTION OF CERTAIN EMBODIMENTS

FIG. 1 is a top-front perspective view of an example embodiment of agonioscope 100. FIG. 2 is a bottom-rear perspective view of the exampleembodiment of a gonioscope 100. The gonioscope 100 can include a handle102 attached to a gonioscopic optical element 104. FIG. 3 is across-sectional view taken through a center of the gonioscopic opticalelement 104. The gonioscope 100 can be configured to be used for viewingstructures inside the eye of a subject, including but not limited to theanterior chamber, trabecular meshwork, iris root, scleral spur, and/orrelated nearby anatomical structures in the eye. FIG. 4 shows across-sectional view of the gonioscopic optical element 104 positionedon the cornea 202 of an eye 200. Light from inside the eye 200 (e.g.,the anterior chamber angle 204) that would normally be hidden from viewby total internal reflection can be permitted to exit the eye throughthe gonioscopic optical element 104. In some instances, an opticalmaterial such as index matching gel, can fill the space between thegonioscopic optical element 104 and the surface of the eye 200 (e.g.,the cornea 202). The light exiting the eye through the gonioscopicoptical element 104 can be viewed by a medical professional (e.g., usinga microscope, using another imaging device, or using the naked eye). Thegonioscope 100 can be used for imaging inside the eye 200 for diagnosticpurposes as well as for treatment, such as during implantation orremoval of a medical device (e.g., for viewing the anterior chamberangle during implantation of a stent into the trabecular meshwork).

The gonioscopic optical element 104 can be a contact lens and caninclude a distal surface 106 having a concave shape that is configuredto contact a surface of a subject's eye, such as the cornea. The distalsurface 106 can have a spherical shape. In some embodiments, the surfaceof the distal surface 106 can be configured to substantially match theshape and size of the cornea of an average eye so as to provide a goodfit with the subject's eye. In some embodiments, the concave distalsurface 106 may have a radius of curvature between about 5 mm and 11 mm,although curvatures outside this range are also possible. In someembodiments, the concave distal surface 106 can have a radius ofcurvature that is larger than the cornea of an average eye. For example,the radius of curvature of the distal surface 106 can be greater than7.5 mm, greater than 8 mm, greater than 9 mm, greater than 10 mm,greater than 11 mm, greater than 12 mm, or any values therebetween, orany ranges bounded by any combination of these values, although valuesoutside these ranges could be used in some instances. The distal surface106 can have a radius of curvature of 15 mm or less. In some instances,bubbles can be formed in the optical material (e.g., index matching gel)when the gonioscopic optical element 104 is place on the eye 200. Adistal surface 106 having a greater radius of curvature than the contactportion on the eye 200 (e.g., the cornea 202) can force the bubbles outof the viewing area (e.g., towards the edges of the gonioscopic opticalelement 104).

The gonioscopic optical element 104 can also include a proximal surface108, which can be planar or have a curved (e.g., spherical or toroidal)shape. In some embodiments, the proximal surface 108 can include animaging portion 108 a and a light diffusing portion 108 b. The imagingportion 108 a can be a smooth surface. As shown in FIG. 4, light fromthe area being imaged inside the eye 200 (e.g., the anterior chamberangle 204) can exit the eye 200 and enter the gonioscopic opticalelement 104 through the distal surface 106. The light can propagatethrough the gonioscopic optical element 104, and can exit thegonioscopic optical element 104 through the imaging portion 108 a of theproximal surface 108. In some embodiments, the light diffusing portion108 b can be omitted, and the entire proximal surface 108 can operate asthe viewing portion 108 b.

The light diffusing portion 108 b can be configured to diffuse lightthat passes through the light diffusing portion 108 b. In someembodiments, the light diffusing portion 108 b can have surfacediffusing features, such as a roughened (e.g., irregular) or frostedsurface, as can be seen for example in FIG. 5. For example, a mold thatis used to make the gonioscopic optical element 104 (e.g., by injectionmolding) can have a roughened mold surface configured to form the lightdiffusing portion 108 b. In some embodiments, the light diffusingportion 108 b can initially be smooth, and the light diffusing portion108 b can be roughened (e.g., by etching or abrasion) to form surfacediffusing features. In some embodiments, a film or coating havingsurface diffusing features can be applied to the light diffusing portion108 b. In some embodiments, the light diffusing portion 108 b can haveembedded diffusing features, such as particulates or voids embedded inthe body of the gonioscopic optical element 104 at the light diffusingportion 108 b, which can be sized and spaced to diffuse light passingthrough the light diffusing portion 108 b.

The light diffusing area 108 b can improve illumination of the structureinside the eye 200 that is being imaged. For example, light from outsidethe gonioscope 100 (e.g., ambient light and/or light from a microscopeor other illumination device) can enter the gonioscopic optical element104 through the light diffusing portion 108 b and can be scattered, ascan be seen in FIG. 4. Some of the scattered light can be directed intothe eye 200 and can illuminate the area being imaged (e.g., the anteriorchamber angle 204). Accordingly, in some cases light that otherwisewould have avoided the area of the eye 200 being imaged can beredirected to the imaging area by the light diffusing portion 108 b.Light entering the gonioscopic optical element 104 through the viewingportion 108 a can also provide illumination to the imaging area.

The light diffusing portion 108 b can also impede the light exiting thegonioscopic through the light diffusing portion 108 b from forming animage. This can focus the attention of the medical professional on theimage formed by the imaging portion 108 a. In many cases, the light thatexits the gonioscopic optical element 104 through the light diffusingportion 108 b is from portions of the eye that are not relevant to thediagnosis or treatment being performed. As discussed further herein,some embodiments can direct light into the eye to provide a fixationpoint for the subject. In some cases, the light diffusing portion 108 bcan diffuse the fixation point light that exits the gonioscopic opticalelement, which can impede the formation of a bright spot that can bedistracting to the medical professional.

The gonioscopic optical element 104 can have a back surface 110. In someembodiments, some or all of the back surface 110 can include a lightdiffusing portion 110 b, which can have features similar to the lightdiffusing portion 108 b of the proximal surface 108. The light diffusingportion 110 b can have surface diffusing feature, or embedded diffusingfeatures, a roughened or frosted surface, etc., as discussed inconnection with the light diffusing portion 108 b. Light from outsidethe gonioscope 100 (e.g., ambient light and/or light from a microscopeor other illumination device) can enter the gonioscopic optical element104 through the back surface 110 and can be scattered by the lightdiffusing portion 110 b, similar to the scattered light in FIG. 4. Someof the scattered light can be directed into the eye 200 and canilluminate the area being imaged (e.g., the anterior chamber angle 204).For example, some of the light that is scattered can reflect off of theback surface 110 of the gonioscopic optical element (e.g., by totalinternal reflection or from a reflective material such as a metalcoating applied to the outside of the back surface 110) to be directedinto the eye 200, as can be seen in FIG. 4. In some cases light thatotherwise would have avoided the area of the eye 200 being imaged can beredirected to the imaging area by the light diffusing portion 110 b. Insome cases light that otherwise would have been focused to a centralpoint due to the curvature of the back surface of the gonioscopicoptical element 404 can be distributed for illuminating the anteriorchamber angle and/or the trabeculum due to the light diffusing portion110 b. In some embodiments, all or portions of the gonioscope 100 (e.g.,one or more of the gonioscopic optical element, the proximal surface108, and the back surface 110) can have an anti-reflective coating,which can improve light transfer through the gonioscope 100.

The gonioscopic optical element 104 can have a generally triangularcross-sectional shape, as can be seen in FIG. 3. The gonioscopic opticalelement 104 can have a wedge shape. The gonioscopic optical element canbe a prism or a lens. The distal surface 106 can be a bottom side, inthat the distal surface 106 is primarily visible when the gonioscope 100is viewed from the bottom. The proximal surface 108 can be a front side,in that the proximal surface 108 is primarily visible when thegonioscope 100 is viewed from the front. The back surface 110 can be aback side of the gonioscopic optical element 104, in that the backsurface 100 is primarily visible when the gonioscope 100 is viewed fromthe back. It will be understood that the back surface 110 is curved suchthat portions of the back surface 110 wrap down onto side areas of thegonioscopic optical element 104.

The proximal surface 108 (e.g., front side) and the back surface 110 canintersect at a first edge. The distal surface 106 (e.g., bottom side)and the back surface 110 can intersect at a second edge. The second edgecan be blunt or rounded, to impede the second edge from injuring the eye200 of the subject. In some embodiments, a bumper 112 can be at a rearportion of the second edge, and can be configured to abut against aneyelid or other tissue adjacent the eye 200 to facilitate positioning ofthe gonioscopic optical element 104 for viewing inside the eye 200. Thebumper 112 can have a crescent shape, and can be formed by theintersection of the distal surface 106 and the back surface 110 at arear of the gonioscopic optical element 104.

The distal surface 106 (e.g., bottom side) and the proximal surface 108(e.g., front side) can intersect at a third edge. The third edge can beblunt or rounded, to impede the third edge from injuring the eye 200 ofthe subject. A recess 114 at a front of the gonioscopic optical element104 can facilitate providing access for a medical tool during surgery.The recess 114 can be crescent shaped. The recess 114 can be formed bythe intersection of the distal surface 106 and the proximal surface 108.As can be seen by comparing FIGS. 7 and 8, the recess 114 can provide alarger recess area for improved access to the wound site during surgery(see FIG. 7), as compared to some gonioscopes where a recess is providedby grinding away material of the gonioscopic optical element (see FIG.8). The gonioscope 100 can be configured to have a recess 114 thatprovides a large recess area while also providing an image of theinterior eye structure (e.g., anterior chamber angle 204) that is spacedaway from the recess 114 (see FIG. 7). Note that for the gonioscope ofFIG. 8, if the recess area were increased to provide more room foraccess to the wound site, the recess area would encroach further intothe image of the eye structure. The recess 114 of the gonioscope 100 canhave a width 116 of greater than 7 mm, greater than 8 mm, greater than 9mm, greater than 10 mm, greater than 11 mm, greater than 12 mm, greaterthan 13 mm, greater than 14 mm, or any values therebetween, or anyranges bounded by any combination of these values, although valuesoutside these ranges can be used in some implementations. The width 116can be less than 15 mm, in some embodiments.

The proximal surface 108 can be angled forward more than a traditionalgonioscope. With reference to FIG. 3, when the gonioscope 100 isoriented with edges of the distal surface 106 flat along a horizontalplane, the proximal surface 108 can be angled away from vertical by anangle 118 that can be 45 degrees, 40 degrees, 35 degrees, 30 degrees, 25degrees less, 20 degrees, 15 degrees, 10 degrees, or any valuestherebetween, or any ranges bounded by any combination of these values,although values outside these ranges can be used in some instances. Insome embodiments, the light can be refracted as it exits the gonioscopicoptical element 104, such as to redirect the light in a more verticaldirection or to otherwise redirect the light towards a microscope orother imaging device. In some embodiments, the curved proximal surfacecan make the image appear larger in the vertical direction. The proximalsurface 108 can be configured (e.g., the orientation and/or curvaturethereof) to direct light entering the proximal surface 108 from a lightsource (e.g., the microscope) to be directed toward the target tissue tobe imaged (e.g., the anterior chamber angle), as compared to some othergonioscopes, which can direct most of the incoming light onto the irisof the eye or other structure not being imaged for the medicalprocedure. In some embodiments, the proximal surface 108 (e.g., theimaging portion 108 a thereof) can be configured to not redirect lightfrom the imaging area (e.g., the anterior chamber angle 204) during use.

The configuration of the gonioscopic optical element 104 can provide animproved viewing location, as compared to other gonioscopes. FIG. 7shows the gonioscope 100 being used to image the anterior chamber angleof the eye (e.g., the trabecular meshwork). In FIG. 7, a medical device300 is in the eye 200, near the trabecular meshwork. In an examplemedical procedure, a medical professional may use a medical tool toremove or reposition a medical device 300 (e.g., a stent) thatimproperly positioned near the trabecular meshwork. The target imagingarea can be positioned in a generally centralized region of the viewingportion 108 a of the gonioscope 100 when the gonioscope is positionedwith the curvature of the distal surface 106 aligned with the curvatureof the contact surface of the eye 200 (e.g., the cornea 202). FIG. 8shows a different gonioscope where the proximal surface of thegonioscopic optical element is angled further back, which can cause thetarget image area to be positioned at the edge of the viewing area or insome cases can impede the formation of an image of the target viewingarea when the distal surface is aligned with the curvature of the eye200. In practice, a medical professional may angle the gonioscope ofFIG. 8 so that the back lifts up away from the eye 200 in order toposition the target image area more in the center of the viewing area onthe gonioscope. Lifting the back of the gonioscope can cause thegonioscope to separate from the optical material (e.g., index matchinggel), as can be seen in FIG. 9, which can impede the formation of theimage. A medical professional may need to remove the gonioscope and addadditional optical material (e.g., index matching gel) to enable imagingwith the gonioscope lifted forward. Also, suspending the gonioscopesteady while angled forward can be difficult, especially since themedical professional would often be operating a medical tool to performa surgical procedure at the same time. Furthermore, as can be seen inFIG. 10, when the gonioscope is angled forward, the gonioscope canencroach into the area (e.g., the wound site) where the medicalprofessional would need to insert the medical tool. In some cases, themedical professional may move the gonioscope back and forth during asurgical procedure to alternate between providing access to the woundsite and providing a suitable image of the target image area. As themedical professional navigates the medical tool during a surgicalprocedure, the medical tool can bump into or rub against the gonioscopewhen angled forward, which can restrict motion of the medical tool orcan impede the medical professional from accurately positioning themedical tool. As can be seen in FIG. 7, the gonioscope 100 can provide agenerally centralized view of the target viewing area while alsoproviding access to the wound site, without angling the gonioscope 100forward. In some embodiments, the gonioscopic optical element can beconfigured to receive illumination light from a light source (e.g., froma microscope that is also used for viewing the image produced by thegonioscope 100) through the proximal surface 108 and to output theillumination light through the distal surface 106 into eye 200. Thegonioscopic optical element 104 can be configured such that the targetstructure being imaged (e.g., the anterior chamber angle 204), such asthe target structure positioned at a center portion of the image (e.g.,center of the viewing portion 108 a), receives more of the illuminationlight than other structures in the eye 200. This can provide improvedillumination of the area being imaged (e.g., the anterior chamber angle204, as can be seen in FIG. 7), as compared to other gonioscopes thatdirect most of the illumination light to a different portion of the eye(e.g., on to the iris 206, as can be seen in FIG. 8) that is notpositioned at the center of the image.

As can be seen by comparing FIGS. 11 and 12, the gonioscopic opticalelement 104 of gonioscope 100 can provide an increased field of view, ascompared to other gonioscopes. The gonioscope 100 can provide a view ofview of 90 degrees, 105 degrees, 120 degrees, 135 degrees, 150 degrees,or any values therebetween, or any range bounded by any combination ofthese values, although values outside these ranges may be used in someimplementations. FIG. 12 shows a different gonioscope that provides afield of view of less than 90 degrees. The gonioscopic optical element104 of the gonioscope 100 can provide magnification of 1.3×, of 1.2×, of1.15×, of 1.1×, of 1.05×, of 0.9×, of 0.8×, of 0.7×, or nomagnification, or any value therebetween, or any range bounded by anycombination of these values, although magnifications outside theseranges can be used in some implementations. The proximal surface 108 canhave a radius of curvature of 14 mm, 15 mm, 16 mm, 17 mm, 18 mm, 19 mm,20 mm, or any values therebetween, or any ranges bounded by anycombination of these values, although values outside of these ranges canbe used in some implementations.

The gonioscopic optical element 104 can be made of a transparentmaterial such as acrylic (e.g., poly(methyl methacrylate)), glass,quartz, silica, plastic, or other material that is suitably transparentso that light can propagate through the gonioscopic optical element 104for imaging structure inside the eye 200. The transparent material doesnot need to transmit all the light that impinges on it. The transparentmaterial can transmit at least sufficient amounts of light to produce animage as discussed herein, while some other light can be absorbed, orreflected, or otherwise not transmitted through the material. The handle102 can be made of the same material as the gonioscopic optical element104. The gonioscope 100 can be a single integrally formed piece thatincludes both the handle 102 and the gonioscopic optical element 104.The gonioscope 100 can be lightweight. The gonioscope 100 can weigh lessthan 5 grams, less than 4 grams, less than 3 grams, or between 1 gramand 2 grams, or any values therebetween, or any range bounded by anycombination of these values, although weights outside of these rangescan be used in some implementations.

The handle 102 can be attached to the back surface 110 of thegonioscopic optical element 104. As discussed, the handle 102 can beintegrally formed with the gonioscopic optical element 104.Alternatively, the handle 102 can be separately formed and coupled tothe gonioscopic optical element 104, such as by an adhesive, a snap fitstructure, a friction fit structure, an intermediate coupling mechanism,etc. The low weight, the low center of gravity, and/or the position ofthe handle 102 can enable the gonioscope 100 to remain in position on aneye 200 when the gonioscope handle 102 resting on a hand or othersupport positioned under the gonioscope handle 102, as can be seen inFIG. 13. Accordingly, a medical professional can grip the gonioscopehandle 102 while positioning the gonioscope 100 (see FIG. 14), and themedical professional can open his/her hand to release the handle 102 andlet the handle 102 rest on his/her hand (see FIG. 13) while viewinginside the eye 200 (e.g., during a surgical procedure). With referenceto FIG. 15, when the gonioscope 100 is oriented with edges of the distalsurface 106 flat along a horizontal plane, the handle 102 can be angledback from a vertical direction by an angle 120 that can be 40 degrees,35 degrees, 30 degrees, 25 degrees less, 20 degrees, 15 degrees, 10degrees, or any values therebetween, or any ranges bounded by anycombination of these values, although values outside these ranges can beused in some instances. With reference to FIG. 16, when the gonioscope100 is oriented with edges of the distal surface 106 flat along ahorizontal plane, the handle 102 can be angled to the side from avertical direction by an angle 122 that can be 45 degrees, 40 degrees,35 degrees, 30 degrees, 25 degrees less, 20 degrees, 15 degrees, or anyvalues therebetween, or any ranges bounded by any combination of thesevalues, although values outside these ranges can be used in someinstances. The handle 102 can be angled to the right side of thegonioscope 100 (see FIG. 16), such as to be operated using the left hand(see FIG. 13). The handle 102 can be angled to the left side of thegonioscope 100, such as to be operated using the right hand. In someembodiments, the handle 102 is not angled to the side, and anambidextrous handle can extend upward, such as from a center of thegonioscopic optical element 104 for use by either the right hand or lefthand.

The handle 102 can have an elliptical cross-sectional shape, as can beseen in FIGS. 14 and 17. The elliptical shape of the handle 102 canencourage proper positioning of the gonioscope 100 when held by theuser, such as between the thumb and index finger, as shown in FIG. 14.If the user holds the handle 102 with the major axis 124 extendingtowards the fingers, applying pressure to the handle 102 can cause thehandle 102 to rotate so that the fingers move closer together with theminor axis 126 extending towards the fingers, as shown in FIG. 14. Theorientation of the minor axis 126 can be configured so that when theuser holds the gonioscope 100 in front of the user (e.g., between thethumb and forefinger) with the wrist and fingers in a natural position,the elliptical shape of the handle 102 encourages the gonioscope 100 tobe oriented with the proximal surface 108 of the gonioscopic opticalelement 104 facing towards the user. With reference to FIG. 17, theminor axis 126 of the elliptical handle 102 can be angled towards thegonioscopic optical element 104 by an angle 128 with respect to an axisextending from front to back. The angle 128 can be 3 degrees, 4 degrees,5 degrees, 6 degrees, 7 degrees, 8 degrees, 9 degrees, 10 degrees, 11degrees, 12 degrees, 13 degrees, 14 degrees, 15 degrees, or any valuestherebetween, or any ranges bounded by any combination of these values,although values outside these ranges can be used in someimplementations.

In some embodiments, light can be directed from the handle 102 into thegonioscopic optical element 104. This light can facilitate illuminationof the eye structure being imaged. FIG. 18 is a cross-sectional view ofthe gonioscope 100 taken along a center of the handle 102. As can beseen in FIG. 18, for example, light can enter the handle 102 and canpropagate along the handle by total internal reflection to thegonioscopic optical element 104. The handle 102 and gonioscopic opticalelement 104 can be integrally made of the same material, so that thelight can transition seamlessly from the handle 102 to the gonioscopicoptical element 104, as can be seen in FIG. 18. In some embodiments, thehandle 102 and gonioscopic optical element 104 can be separately formedand optically coupled to enable light to propagate from the handle 102to the gonioscopic optical element 104, such as by an optical adhesive,an index matching material, etc. In some embodiments, scatteringelements (not shown) can scatter the light, such as at the transitionfrom the handle 102 to the gonioscopic optical element 104 to facilitateillumination of the structure in the eye 200.

In some embodiments, light can enter the handle 102 of the gonioscope100 at one or more light entry areas 130 a-c. In the example embodimentsshown in FIGS. 13 and 15-18, the handle can include two light entryareas 130 a and 130 b. The one or more light entry areas 130 a-b can bepositioned on the front side of the handle 102. In some cases, lightfrom a microscope or other illumination device can illuminate thegonioscope 100 from the front side. The light can be directed into thegonioscopic optical element 104, such as through the proximal surface108, as discussed herein. As can be seen in FIG. 18, the light can alsoenter the handle 102 at the one or more light entry areas 103 a-b. Insome embodiments, light entry areas can be positioned at other locationson the handle 102, such as to enable ambient light to enter the handle102. As shown in FIG. 14, in some embodiments, the handle 102 caninclude a light entry area 130 c on the top end surface of the handle102, which can allow light to enter the handle 102 and propagate to thegonioscopic optical element 104 by total internal reflection. Lightentry areas can be positioned at other locations as well, such as on theback or other sides of the handle 102. In some embodiments, light canenter the handle through the surfaces of the handle 102 that do not havededicated light entry areas 103 a-c. Light can refract as it passesthrough a surface of the handle 102 and can be redirected by therefraction so that the light propagates along the handle to thegonioscopic optical element 104 by total internal reflection. The lightentry areas 130 a-c can have one or more angled surfaces, such as a sawtooth structure, that are configured to refract light, such as from amicroscope or other illumination device directing light to the frontside of the gonioscope 100, so that the refracted light propagates bytotal internal reflection to the gonioscopic optical element 104, as canbe seen for example in FIG. 18.

In some embodiments, the gonioscope 100 can be configured to provide anoptical fixation point, which can facilitate alignment and/or steadyingof the eye 200. An optical fixation point can be used to help a patientorient their eye to align with the gonioscopic optical element 104, amicroscope, a surgical tool, a measurement device, a medicalprofessional, etc. A subject can focus his/her vision on the opticalfixation point to facilitate keeping the eye steady during a medicalprocedure (e.g., surgery or a diagnostic measurement). In someprocedures, a subject's head it ordinarily tilted at an angle to providethe appropriate orientation of the eye 200 for the procedure. In somecases, a subject can focus on the optical fixation point to provide areliable tilting of the eye 200 relative to the head, so that thepatient can avoid tilting the head during the procedure, which canresult in improved patient comfort. The optical fixation point can beused with the gonioscopes discussed herein during procedures andtreatments such as, for example, glaucoma surgery (e.g., minimallyinvasive glaucoma surgery (MIGS), laser trabeculoplasty, fundus laser,vitrectomy laser, and suture lysis optics where ocular retention andeye/lens stabilization would be beneficial).

In some embodiments, light can be directed into the gonioscopic opticalelement 104 from the handle 102, as discussed herein, and this light canproduce a bright spot that can be used as the optical fixation point.The subject can focus his or her vision on the bright spot to stabilizeand/or align the eye 200. The handle 102 can join the gonioscopicoptical element 104 at a joint location 132 that corresponds to thedesired orientation of the eye 200, so that the bright spot formed bylight entering the gonioscopic optical element 104 through the jointlocation 132 is at a location the aligns with the vision axis of the eye200 when the eye is properly aligned with the gonioscope 100. In someembodiments, the joint location 132 of the handle 102 to the gonioscopicoptical element 104 can be at a different location than shown in FIG.17, in order to produce an optical fixation point. For example, thejoint location can be located at position 133 shown in FIG. 17. Thejoint location can be along a center plane of the gonioscopic opticalelement 104. The joint location can be at a location 133 that causes theeye 200, when focused on the optical fixation point, to be angledrelative to the vertical direction by an angle of 15 degrees, 20degrees, 25 degrees, 30 degrees, 35 degrees, 40 degrees, 45 degrees, orat any angle between these values, or any range bounded by anycombination of the these values, although values outside these rangedcan be used in some instances.

In some embodiments, the gonioscope 100 can include an optical fixationpoint light guide 134. With reference to FIG. 19, the light guide 134can have a light entry surface 136, which can face forward, such as toreceive light from a microscope or other illumination device. A lightpropagation region 138 can propagate the light (e.g., by total internalreflection) to an illumination point 140, where the light can beredirected (e.g., by refraction or scattering) to the eye (e.g., throughthe gonioscopic optical element 104 in some embodiments). Theillumination point 140 can be positioned at a location that correspondsto the desired orientation of the eye 200, so that a bright spot formedby from the light guide 134 is at a location that aligns with the visionaxis of the eye 200 when the eye is properly aligned with the gonioscope100. In some embodiments, the propagation region 138 can be tapered sothat the light guide 134 gets thinner from the light entry surface 136to the illumination point 140. The light entry surface 136 can gather arelatively large amount of light and the tapered light propagationregion 138 can concentrate that light to the illumination point 140, sothat the illumination point 140 appears visible to the subject as abright spot. The light guide 134 can be made of a different materialthan the handle 102, such as a plastic or glass material, which in someembodiments can have a higher index of refraction than the handle 102.In some embodiments, the light guide 134 can extend through the handle102. For example a bore can be formed in the handle 102, and the lightguide 134 can extend through the bore. In some cases, an adhesive cansecure the light guide 134 to the handle 102. The adhesive can have alower index of refraction than the material of the light guide 134. Insome embodiments, the light guide 134 can propagate light outside thehandle 102, instead of through the handle 102. For example, withreference to FIG. 20, the light guide 134 can attach to the handle 102,such as be a clip 142 or friction fit, etc., so that the light guide 134is suspended next to the handle 102. The light guide 134 can be shapedto position the illumination point behind the handle 102, for example.Various other types of optical fixation points can be used, such asthose described in WO 2016/154066.

The light diffusing portion 108 b can diffuse light from the opticalfixation point to impede the medical professional from seeing theoptical fixation point, which can be distracting, as discussed herein.The light diffusing portion 108 b can impede the light of the opticalfixation point from reflecting off the proximal surface 108 to make asecondary bright spot, which could be distracting or confusing for thesubject.

FIG. 21 is a top-front perspective view of an example embodiment of agonioscope 400. FIG. 22 is a bottom-rear perspective view of the exampleembodiment of a gonioscope 400. FIG. 23 is a front view of the exampleembodiment of a gonioscope 400. FIG. 24 is a cross-sectional view of theexample embodiment of a gonioscope 400 taken at plane 24-24 shown inFIG. 23. The gonioscope 400 can have features that are the same as, orsimilar to, features of the gonioscope 100. Many features discussed inconnection with the gonioscope 100 can apply also to the gonioscope 400and are not discussed in detail in connection with the gonioscope 400for sake of brevity.

The gonioscope 400 can include a handle 402 and a gonioscopic opticalelement 404. The gonioscopic optical element 404 can include a distalsurface 406 and a proximal surface 408, similar to the gonioscope 100.In some embodiments, the proximal surface 108 can have a generallyrectangular profile from the front, as can be seen in FIG. 23, which canfacilitate gathering of light into the gonioscopic optical element 404to illuminate the eye 200. In some embodiments, the gonioscope 400 canhave flat surfaces, other than the curved distal contact surface 406 andthe curved proximal surface 408, which is used for viewing the image ofthe eye 200. The gonioscopic optical element 404 can have a back surface410 that is flat. The back surface 410 can reflect light (e.g., by totalinternal reflection or using a reflective material such as a metalcoating applied to the outside of the gonioscope 400 at the back surface410) to redirect light into the eye 200, to illuminate the targetstructure being imaged. The flat shape of the back surface 410 canfacilitate distributing the light across the imaging are of the eye 200,as opposed to focusing the light as can occur with a curved back surfaceof the gonioscopic optical element 404.

The gonioscope 400 can have one or more retention elements 444, whichcan be configured to engage tissue of the eye 200, such as scleraltissue around the cornea, to retain the gonioscope 400 in positionedrelative to the eye 200. The one or more retention elements 444 can bepositioned on the distal side of one or more arms 446. The one or moreretention elements 444 and the one or more arms 446 can include featuresthat are the same as, or similar to features of the retention elementsand arms described in the WO 2016/154066 publication, which isincorporated herein by reference. Although not shown in the exampleembodiments illustrated in the Figures, the gonioscope 100 can includeone or more retention elements and/one or more arms, similar to thosedisclosed in connection with the gonioscope 400.

The handle 402 can connect to the gonioscopic optical element 404 at ajoint location 432 that extends across the full length of the top edgeof the gonioscopic optical element 404, or across at least 90%, at least80%, at least 70%, at least 60%, or at least 50% of the top edge of thegonioscopic optical element 404, or any values therebetween, or anyranges bounded by any combination of these values, although valuesoutside these ranges can be used in some instances. The wide jointlocation 432 can provide improved strength to the connection between thehandle 402 and the gonioscopic optical element 404, and can impede thegonioscope 400 from breaking, such as when being used to restrain theeye using the retention elements 444.

The handle 402 can extend straight upward from the gonioscopic opticalelement 404, not angled to either the left side or right side, so thatthe handle is ambidextrous for use by either the right hand or lefthand. The gonioscope 400 can be symmetrical across the plane 24-24 ofthe cross-sectional view of FIG. 24, which extends across the middle ofthe gonioscope 400. The right and left sides of the gonioscope 400 canbe symmetrical to each other. The gonioscope 400 can be configured suchthat the handle 402 extends generally vertically upward when positionedon the eye oriented for viewing the anterior chamber angle. The handle402 can be angled by 20 degrees, 15 degrees, 10 degrees, 5 degrees, or 0degrees relative to the vertical direction, or any values therebetween,or any ranges bounded by any combination of these values, althoughvalues outside these ranges can be used in some instances. The center ofgravity of the gonioscope 400 can be positioned generally above the eye200, which can facilitate maintenance of the gonioscope 400 at theproper position relative to the eye 200 with little input from themedical professional. In some cases the medical professional can releasethe gonioscope 400, and the gonioscope 400 can stay in place even whennot being held or supported by the medical professional (e.g., handsfree). The one or more retentions elements 444 and/or the one or morearms 446 can provide a base for the gonioscope 400 that is larger thanthe distal surface 406 of the gonioscopic optical element 404, tofacilitate stabilizing of the gonioscope 400. The handle 402 of thegonioscope 400 can be positioned to be held by the medical professionalin a natural position (e.g., without needing muscles to flex to maintainthe position) when aligned with the eye. Some gonioscopes can requirethe medical professional's hand to rotate outwardly to hold the handleof the gonioscope in position, which can be difficult to maintainespecially over long periods of time such as during a medical procedure.

In some embodiments, the gonioscope 400 can be configured to attach to alid speculum 500. FIG. 25 shows the gonioscope 400 and lid speculum 500separate from each other. FIG. 26 shows the gonioscope 400 coupled tothe lip speculum 500. The gonioscope 400 can include one or morecoupling elements that are configured to attach to attachment portionsof the lid speculum 500. The lid speculum can have a right-side eyeengagement piece 502 a and a left-side eye engagement piece 502 b, whichare configured to engage the upper and lower eyelids. A biasing member504 can bias the right-side eye engagement piece 502 a and the left-sideeye engagement piece 502 b away from each other, to hold the eye 200 ofa subject open. The lid speculum 500 can have attachment portions, suchas posts 504 a and 504 b that are configured to attach to the gonioscope400. The right post 504 a can extend upward from the right-side eyeengagement piece 502 a. The left post 504 b can extend upward from theleft-side eye engagement piece 502 b. The gonioscope 400 can have aright wing 448 a that extends (e.g., horizontally) from the right sideof the gonioscope 400 and a left wing 448 b that extends (e.g.,horizontally) from the left side of the gonioscope 400. The right wing448 a and the left wing 448 b can have holes that are configured toreceive the respective right post 504 a and left post 504 b. The holesin the wings 448 a-b can be elongate slots extending to the right andleft, to provide a range of motion for the posts 504 a-b to move withinthe holes as the right-side eye engagement piece 502 a and the left-sideeye engagement piece 502 b move relative to each other. The attachmentof the gonioscope 400 to the lid speculum 500 can stabilize thegonioscope 400 on the eye 200, such as when a medical professionalreleases the gonioscope for hands-free use of the gonioscope 400. Thegonioscope 100 can also be configured to couple to a lid speculum, suchas using wings or other coupling members.

FIG. 27 shows a top-front perspective view of an example embodiment of agonioscope 600. FIG. 28 shows a bottom-rear perspective view of anexample embodiment of a gonioscope 600. FIG. 29 is a top-down view of anexample embodiment of a gonioscope 600, where the proximal surface isshown transparent to illustrate the surfaces inside the gonioscope 600.FIG. 30 is a perspective, cross-sectional view of an example embodimentof a gonioscope 600. FIG. 31 is a cross-sectional view of an exampleembodiment of a gonioscope 600 positioned on an eye 200. The gonioscope600 can have features that are the same as, or similar to, features ofthe other gonioscopes 100 and 400 disclosed herein. Many featuresdiscussed in connection with the gonioscopes 100 and 400 can apply alsoto the gonioscope 600 and are not discussed in detail in connection withthe gonioscope 600 for sake of brevity.

The gonioscope 600 can include a handle 602 and a gonioscopic opticalelement 604. The handle 602 can be a gripping portion positioned at theperiphery of the upper portion of the gonioscope 600. The handle 602 canextend around all or a portion of the periphery of the gonioscopicoptical element 604 (e.g., at an upper end or portion of the gonioscopicoptical element 604). The handle 602 can be annular, although othershapes can be used such as a square or rectangular handle 602. In someembodiments, the handle 602 and the gonioscopic optical element 604 canbe integrally formed of the same material, such as by injection moldingof a single piece. The gonioscopic optical element 604 can be made of atransparent material such as acrylic (e.g., poly(methyl methacrylate)),glass, quartz, silica, plastic, or other material that is suitablytransparent so that light can propagate through the gonioscopic opticalelement 604 for imaging structure inside the eye 200. The handle 602 canbe made of the same material as the gonioscopic optical element 604. Insome embodiments, the handle 602 can include a textured surface, such asthe radially outward facing surface, to facilitate gripping by the user.In some embodiments, the handle 602 can include a different materialthan the gonioscopic optical element 604. For example, the handle 602can include an elastomeric material to facilitate gripping of the handle602 by the user. A sleeve (not shown) can fit over a portion of thegonioscope to form the handle, and can include an elastomeric materialto facilitate gripping of the handle 602. In some embodiments, thehandle 602 can include a shaft, similar to the handles 102 and 402disclosed herein. In some embodiments, the handle 602 can be omitted.For example, a user can grip the sides of the gonioscopic opticalelement 604 directly, or the gonioscope 600 can be configured forhands-free operation.

The gonioscopic optical element 604 can include a first portion 604 aand a second portion 604 b, which can be separated such as by a gap(e.g., and air gap) or an intermediate material that is different thanthe material of the gonioscopic optical element. The space between thefirst portion 604 a and the second portion 604 b of the gonioscopicoptical element 604 can increase in width along the downward direction.In some embodiments, the first portion 604 a and the second portion 604b of the gonioscopic optical element 604 can be joined at an upper end,and can diverge away from each other in the downward direction. Thefirst portion 604 a can be configured to export an image of thestructure inside the eye 200 (e.g., the anterior chamber angle 204), asdiscussed herein. The second portion 604 b can be configured to directlight into the eye 200 for illumination of the eye structure beingviewed, as discussed herein. In some embodiments, light can also bedirected into the eye for illumination through the first portion 604 a.

The gonioscope 600 can include two or more separate, spaced apartcontact surfaces 606 a and 606 b that are configured to contact theuser's eye to transmit light to and/or from the eye 200. The firstportion 604 a of the gonioscopic optical element 604 can include a firstdistal contact surface 606 a. The second portion 604 b of thegonioscopic optical element 604 can include a second distal contactsurface 606 b. The first distal surface 606 a and/or the second distalsurface 606 b can be concave, and can have a spherical curved shape, andcan be configured to fit onto a structure of the eye 200, such as thecornea 202. The radius of curvature of the first distal surface 606 aand/or the second distal surface 606 b can be greater than 5 mm, greaterthan 7.5 mm, greater than 8 mm, greater than 9 mm, greater than 10 mm,greater than 11 mm, greater than 12 mm, or any values therebetween, orany ranges bounded by any combination of these values, although valuesoutside these ranges could be used in some instances. The first distalsurface 606 a and/or the second distal surface 606 b can have a radiusof curvature of 15 mm or less. The first distal surface 606 a and thesecond distal surface 606 b can have the same radius of curvature. Thefirst distal surface 606 a and the second distal surface 606 b can lieon the same sphere.

In some embodiments, the gonioscope 600 can be configured to impedelight from the light source (e.g., the surgical microscope) fromreaching the retina of the eye 200, such as via the surface 605. Thiscan enable the medical professional to increase the amount of lightbeing used for illumination, without that light causing discomfort tothe subject or damage to the eye 200. For example, the space between thefirst distal contact surface 606 a and the second distal contact surface606 b can be positioned on a center (e.g., apex) of the cornea 202, canbe positioned between the light source (e.g., the surgical microscope)and the optical axis of the eye or the visual axis of the eye. The gapbetween the first portion 604 a and the second portion 604 b of thegonioscopic optical element 604 can be configured to be positioned overa center (e.g., apex) of the cornea 202. The gap between the firstportion 604 a and the second portion 604 b of the gonioscopic opticalelement 604 can be configured to intersect the optical axis of the eye200 and/or the visual axis of the eye 200. The gap between the firstportion 604 a and the second portion 604 b of the gonioscopic opticalelement 604 can be configured to be positioned between the retina of theeye 200 and the light source (e.g., a surgical microscope, which candirect light directly downward, in some implementations). A surface 605of the gonioscopic optical element 600 can be configured to block lightfrom the light source (e.g., the surgical microscope) from entering theeye 200 along the optical axis and/or along the visual axis. The surface605 can have an opaque material (e.g., a reflective material) forblocking (e.g., redirecting by reflection) the light that wouldotherwise be directed from the light source to the retina of the eye200. The surface 605 can be oriented to reflect light from the lightsource (e.g., directed along a downward direction such as from asurgical microscope), such as by total internal reflection. In someembodiments, light can be redirected (e.g., reflected) to enter the eyeat a different angle, that is not directed towards the retina, such asto illuminate the anterior chamber of the eye 200. In some cases, somelight can reach the retina, such as after being reflected or scatteredby structures in the eye. The gonioscope 600 can be configured to impedelight that enters the proximal surface 608, such as from the lightsource (e.g., surgical microscope), from reaching the retina of the eyewithout being reflected or scattered. The gonioscope 600 can beconfigured to block 95%, 90%, 85%, 80%, 75%, 70%, 65%, or 60% of thelight from the light source (e.g., surgical microscope) that would reachthe retina if the gonioscope 600 were removed from reaching the retina,or any values between these percentages, or any ranges bounded by anycombination of these percentages, although values outside thesepercentages can be used in some instances. In some instances, thegonioscope 600 can be configured to direct a portion of the light fromthe light source into the eye to produce a visible optical fixationpoint, as discussed herein.

The gonioscopic optical element 604 can include a proximal surface 608,which can be shared by both the first portion 604 a and the secondportion 604 b of the gonioscopic optical element 604. The proximalsurface 608 can be curved (e.g., having a spherical curved shape), ascan be seen in FIGS. 30 and 31. The proximal surface 608 can be convex.The proximal surface 608 can be curved to prevent the reflected lightfrom the light source (e.g., microscope) from interfering with the viewof the image of the eye 200 produced by the gonioscope 600. Thegonioscope can provide an image of the structure inside the eye withmagnification of 1.3×, of 1.2×, of 1.1×, of 1.05×, of 0.9×, of 0.8×, of0.7×, or no magnification (0.0×), or any value therebetween, or anyrange bounded by any combination of these values, althoughmagnifications outside these ranges can be used in some implementations.In some embodiments, the proximal surface 608 can be planar, concave,toroidal, or can have any other suitable shape. The gonioscope 600 canbe configured so that the proximal surface 608 faces upward when thegonioscope 600 is positioned on the eye for viewing the structure insidethe eye, such as varying from a vertical direction by 0 degrees, 2degrees, 5 degrees, 10 degrees, 15 degrees, 20 degrees, or any valuestherebetween, or any ranges bounded by any combination of these values.The light source (e.g., microscope) can direct light downward into theproximal surface 608 of the gonioscope 600. The gonioscope 600 candirect light forming an image of the structure in the eye 200 in anupward direction (e.g., to the microscope positioned above thegonioscope 600). In some cases, the gonioscope 600 can be used withouttilting the subjects head to the side and/or with the eye 200 alignedstraight forward, which can facilitate patient comfort during use of thegonioscope 600.

With reference to FIG. 31, light from inside the eye 200 (e.g., theanterior chamber angle 204) that would normally be hidden from view bytotal internal reflection can be permitted to exit the eye through thefirst portion 604 a of the gonioscopic optical element 604. In someinstances, an optical material such as index matching gel, can fill thespace between the gonioscope 600 and the surface of the eye 200 (e.g.,the cornea 202). Light from the area being imaged inside the eye 200(e.g., the anterior chamber angle 204) can exit the eye 200 and enterthe gonioscopic optical element 604 through the first distal surface 606a. The light can propagate to a first reflection surface 607, where thelight can be reflected towards a second reflection surface 605, wherethe light can be reflected upward, and the light than then exit thegonioscope 600 through the proximal surface 608. Although not shown inFIG. 31 for sake of simplicity, the light can be refracted as it exitsthe proximal surface 608, and/or as it transitions from the eye to thegonioscope 600 at the distal surface 606 a. The light forming the imagecan be reflected twice, so that the gonioscope 600 provides an uprightimage that is not inverted. The first reflection surface 607 can bepositioned radially outward from the second reflection surface 607. Thefirst reflection surface 607 can be on a side of the first portion 604 aof the gonioscopic optical element 604 that is opposite the secondreflection surface 605. One or both of the first reflection surface 607and/or the second reflection surface 605 can include a reflectivematerial to facilitate reflection of light. For example, a metal coatingcan be applied to the outside of the gonioscope 600 at the firstreflection surface 607 and/or the second reflection surface 605. In someembodiments, the reflective material can be opaque, and can block lightfrom outside the gonioscope 600 from propagating down through thecentral region of the gonioscope 600 and into the eye 200, as discussedherein. In some embodiments, the first reflection surface 607 and/or thesecond reflection surface 605 can be oriented so that light is reflectedby total internal reflection.

The first reflection surface 607 and/or the second reflection surface605 can be planar. In some embodiments, one or both of the firstreflection surface 607 and the second reflection surface 605 can becurved, which can adjust the field of view and/or magnification of theimage produced by the gonioscope 600. One or both of the reflectionsurface 607 and the second reflection surface 605 can be concave orconvex in one or both of the horizontal and vertical directions, toadjust the image produced by the gonioscope 600. By way of example, withreference to FIGS. 32 and 33, the first reflecting surface 607 can beconvex on the inside surface that reflects light, which can increase thefield of view of the image produced by the gonioscope 600. The secondreflecting surface 605 can be planar. In some embodiments, the secondreflection surface 605 can have a larger area than the first reflectionsurface 607, and the first reflection surface 607 can be configured todiverge the reflected light so light reflected by smaller area of thefirst reflection surface 607 can reflect from a larger area on thesecond reflection surface 605, which can increase the size of the imageproduced by the gonioscope. Many alternatives are possible. The firstreflecting surface 607 can be convex on the inside surface that reflectslight in the horizontal direction (see FIG. 33) and linear in thevertical direction, to diverge the light in the horizontal direction.The second reflecting surface 605 can be convex on the inside surfacethat reflects light in the vertical direction and linear in thehorizontal direction, to diverge the light in the vertical direction.The second reflecting surface 605 can be convex on the inside surfacethat reflects light, while the first reflecting surface 607 can beplanar. The first reflecting surface 607 can be convex on the insidesurface that reflects light in the vertical direction (see FIG. 32) andlinear in the horizontal direction. The second reflecting surface 605can be convex on the inside surface that reflects light in thehorizontal direction and linear in the vertical direction. Each of theexamples provided above can be modified to have concave curvature on theinside surface that reflects the light, so as to increase magnificationof the image.

The gonioscopic optical element 604 can direct light from the lightsource (e.g., the microscope) into the eye 200 to illuminate thestructure being imaged (e.g., the anterior chamber angle 204), such asthrough the second portion 604 b. As can be seen in FIG. 31, light fromthe light source (e.g., the microscope) can propagate downward and enterthe gonioscope 600 through the proximal surface 608, can propagatethrough the second portion 604 b of the gonioscopic optical element 604to the second distal surface 606 b, where the light can transition fromthe gonioscope 600 to the eye 200. The second distal surface 606 b canbe configured to be positioned over the area of the eye 200 beingimaged, such as over the anterior chamber angle 204.

In some embodiments, some of the light can reflect off of one or both ofthe side surfaces 609 and 611 of the second portion 604 b of thegonioscopic optical element 604. One or more of the side surfaces 609and 611 can be angled to receive the light that enters the proximalsurface 608 and to reflect the light so that it is redirected towardsthe structure in the eye 200 being imaged (e.g., the anterior chamberangle 204). FIG. 31 shows light reflecting off of surface 609 to bedirected towards the anterior chamber angle 204. One or more of thesurface 609 and 611 can be angled so that they draw closer together inthe downward direction. The area of the proximal surface 608 thatcollects light into the second portion 604 b of the gonioscopic opticalelement 604 can be larger than the second distal surface 606 b thatoutputs the light into the eye 200. The light entering the secondportion 604 b of the gonioscopic optical element 604 can be concentratedas it propagates downward towards the distal surface 606 b, such as byreflecting off of one or more of the sides 609 and 611 of the secondportion 604 b of the gonioscopic optical element 604. In someembodiments, the surface 609 can be planar, and the surface 611 can becurved, such as having a semicircular cross-sectional shape, as can beseen in FIG. 29. In some embodiments, the second portion 604 b of thegonioscopic optical element 604 can have 3 sides, 4 sides, 5 sides, 6sides, or more, each of which can be planar or curved. In someembodiments, the second portion 604 b of the gonioscopic optical element604 can have a continuously curved side wall, such as in the shape of atruncated cone. One or more of the side walls 609 and 611 can have areflective material to facilitate reflection of the light. For example,a metal coating can be applied to the outside of the gonioscope 600 atthe side walls of the second portion 604 b of the gonioscopic opticalelement 604. In some embodiments, one or more of the side walls 609 and611 can be oriented to reflect light by total internal reflection.

Some of the light can be directed through the gonioscope 600 and intothe eye without any reflections, as can be seen in FIG. 31. Some of thelight can be directed through the gonioscope 600 and into the eye with asingle reflection, as can be seen in FIG. 31. This can avoid lightlosses that can occur when the light is reflected multiple times beforebeing provided to the eye 200 for illumination, as is the case with somegonioscopes, especially double-reflection gonioscopes that provide bothlight input for illumination and light output for producing an image byreflecting the light twice. The gonioscope 600 can be configured toprovide 50%, 60%, 70%, 80%, 90% of the light that impinges on theportion of the proximal surface 608 that corresponds to the secondportion 604 b of the gonioscopic optical element 604 to the eye, or anyvalues between these percentages, or any ranges bounded by anycombination of these percentages, although values outside thesepercentages can be used in some instances. Although not shown in FIG. 31for sake of simplicity, the light can be refracted as it exits theproximal surface 608, and/or as it transitions from the eye 200 to thegonioscope 600 at the distal surface 606 b. Although not shown in FIG.31, light from the first portion 604 a of the gonioscopic opticalelement 604 can be used to illuminate the eye 200. For example, light(e.g., propagating downward from the light source, such as a microscope)can enter the proximal surface 608 over the first portion 604 a of thegonioscopic optical element 604, can reflect off of the secondreflection surface 605, can reflect off of the first reflection surface607, and can exit the gonioscope 600 through the first distal contactsurface 606 a to enter the eye 200. This light can follow a path that isopposite to the path of light that produces the image, which isillustrated in FIG. 31.

In some embodiments, the gonioscope 600 can be configured to provide anoptical fixation point, which can facilitate alignment and/or steadyingof the eye 200, as discussed herein. The gonioscope 600 can include alight redirecting feature to redirect light to produce the opticalfixation point. For example, the gonioscope 600 can have an opticalfixation point reflection surface 613, which in some embodiments can beformed as a recess in the surface 611 of the second portion 604 b of thegonioscopic optical element 604. As can be seen in FIG. 31, the opticalfixation point reflection surface 613 can be configured to reflect lightacross the second portion 604 b of the gonioscopic optical element 604,through the surface 609, across the gap between the first portion 604 aand the second portion 604 b of the gonioscopic optical element 604, tothe outside of surface of the second reflection surface 605, where thelight can be reflected downward into the eye 200 (e.g., along theoptical axis or visual axis of the eye 200), so that the light reachesthe retina to provide a visible bright spot to the subject. The secondreflection surface 605 can have two reflective surfaces. A reflectivematerial on the second reflection surface 605 can have two reflectivesurfaces, with a first reflective surface facing inward to reflect lightpropagating inside the first portion 604 a of the gonioscopic opticalelement 604, and a second reflective surface facing outward to reflectlight to produce the optical fixation point. In some embodiments, thesurface 609 can have a reflective material (e.g., a metal coating),which can have an aperture 615 to enable light for the optical fixationpoint to pass through the surface 609. In some embodiments, the lightredirecting feature can include scattering features, such as surfacediffusing feature or embedded diffusing features, which can scatter someof the light propagating through the second portion 604 b of thegonioscopic optical element 604, and some of the scattered light canexit the surface 609 through the aperture 615 to form the opticalfixation point.

In some embodiments, the gonioscope 600 can have one or more retentionelements and/or one or more arms similar to those discussed inconnection with the gonioscope 400. The gonioscope 600 can include ahandle that is similar to the handles disclosed in connection with thegonioscopes 100 and 400. The gonioscope 600 can include wings similar tothose disclosed in connection with the gonioscope 400, or can otherwisebe configured to couple to a lid speculum.

FIG. 34 is a top-front perspective view of an example embodiment of agonioscope 700. FIG. 35 is a top-rear perspective view of the exampleembodiment of a gonioscope 700. FIG. 36 is a bottom-front perspectiveview of the example embodiment of a gonioscope 700. FIG. 37 is across-sectional perspective view of the example embodiment of agonioscope 700 taken at line 37-37 shown in FIG. 36. FIG. 38 is across-section view of the example embodiment of a gonioscope 700 takenat line 38-38 shown in FIG. 36. The gonioscope 700 can have featuresdiscussed in connection with the other gonioscopes 100, 400, 600disclosed herein. Many features discussed in connection with thegonioscopes 100, 400, 600 can apply also to the gonioscope 700 and arenot discussed in detail in connection with the gonioscope 700 for sakeof brevity.

The gonioscope 700 can include a handle 702 and a gonioscopic opticalelement 704. In some embodiments, the handle 702 and the gonioscopicoptical element 704 can be integrally formed of the same material, suchas by injection molding of a single piece. The gonioscopic opticalelement 704 and/or the handle 702 can be made of a transparent material,as discussed herein. The handle 702 can be an ambidextrous handle,similar to the handle 402 of the example gonioscope 400 disclosedherein. The gonioscope 700 can be symmetrical across the plane of thecross-sectional view of FIG. 38, which extends through the middle of thehandle 702 and the rest of the gonioscope 700. The gonioscope 700 can beconfigured such that the handle 702 extends generally vertically upwardwhen positioned on the eye oriented for viewing the anterior chamberangle, and/or such that the center of gravity of the gonioscope 700 canbe positioned generally above the eye, similar to the gonioscope 400.

The handle 702 can have a cross-sectional shape that can be generallycircular, round, oval, elliptical, or polygonal. This shape can enable amedical practitioner to rotate the gonioscope 700 by twisting the handle702 between the practitioner's fingers. This can be useful, for example,in a medical procedure where the practitioner desires to view multipleareas in the eye, or to view a large area in the eye. For example, bytwisting the handle in the fingers the proximal surface 708 can berotated thereby allowing the practitioner to view further left or rightin the eye as the refractive angle is increased. By comparison, thehandle 402 of the gonioscope 400 can be more difficult to rotate betweenthe fingers. The gonioscope 400 can be rotated by moving the wrist. Thegonioscope 400 can be useful, for example, in medical procedures wherethe practitioner desires to focus on a single or small area. The widehandle 402 of gonioscope 400 can impede unintentional rotation of thegonioscope 400. The gonioscope 700 can have a handle 702 as shown in thefigures or can have a handle 402 similar to the gonioscope 400. Thehandle 702/402 can have a ratio between the width (e.g., along adirection 705 extending between the right and left sides of thegonioscope 700) and the depth (e.g., along a direction 707 extendingbetween the front and back sides of the gonioscope 700) of 8 to 1, 6 to1, 5 to 1, 4 to 1, 3.5 to 1, 3 to 1, 2.5 to 1, 2 to 1, 1.75 to 1, 1.5 to1, 1.25 to 1, 1.1 to 1, 1 to 1, 1 to 1.1, 1 to 1.25, 1 to 1.5, or anyvalues therebetween, or any ranges bounded by any combination of thesevalues, although other values can be used in some cases.

The handle 702 can have one or more touch features 703, which can befelt by the practitioners fingers while holding the handle 702 toprovide an indication of the location on the handle 702 that is beingheld. The one or more touch features 703 can be wider or narrower thanthe main shaft of the handle 702. In FIGS. 34 to 36, the handle 702 hasa single touch feature 703 (e.g., a widened region) at a top of thehandle 702 to indicate to the practitioner when the gripping location isnear the top of the handle 702, which can impede accidental dropping ormistaken positioning of the gonioscope 700. The one or more touchfeatures 703 can be one or more ridges, indentations, tear-drop shapedfeatures, rough areas, etc. The handle 702 can connect to thegonioscopic optical element 704 at a junction area 732, which can betapered from the top of the gonioscopic optical element 704 towards thehandle 702. The junction area 732 can serve as a touch feature toindicate that the gripping location is near the base of the handle 702when the user feels the widening of the juncture area 732.

The gonioscopic optical element 704 can include a distal surface 706 anda proximal surface 708, similar to the other gonioscopes 100, 400, 600disclosed herein. Many features discussed in connection with thegonioscopic optical elements 104, 404, 604 can apply to the gonioscopicoptical element 704 of the gonioscope 700 even though not expresslydiscussed. The proximal surface 708 can have an aspherical shape. Theproximal surface 708 can have a biconic shape, can conform to a portionof a hyperboloid, can conform to an inside portion of a toroid, or anyother suitable geometric shape. The proximal surface 708 can be convexalong a first direction or axis 709 and/or can be concave along a seconddirection or axis 711, which can be orthogonal to the first axis 709.The first axis 709 can correspond to a height of the produced image, andthe second axis can correspond to a width of the produced image. Theconvex curvature along the first axis 709 can be seen in FIG. 34, and inthe cross-sectional view of FIG. 38. The concave curvature along thesecond axis 711 can be seen in FIG. 34, and in the cross-sectional viewof FIG. 37. The convex curvature along the first axis 709 can produce amagnification along a first direction or axis of the image (e.g., theheight of the image), and the magnification can be 1.1×, 1.2×, 1.3×,1.4×, 1.5×, 1.6×, or any values therebetween, or any ranges bounded byany combination of these values, although amounts of magnification canbe produced in some embodiments. The concave curvature along the secondaxis 711 can produce a demagnification along a second direction or axisof the image (e.g., the width of the image), and the demagnification canbe 0.95×, 0.9×, 0.85×, 0.8×, 0.75×, 0.7×, 0.65×, 0.6×, or any valuestherebetween, or any ranges bounded by an combination of these values,although other amounts of demagnification can be produced in someembodiments.

The image can provide more detail of the imaged tissue in the first axis(e.g., the height of the trabecular meshwork, anterior angle, etc.),while also provide a wide field of view. In some cases, thedemagnification can be used so that the size of the gonioscopic opticalelement 704 can be reduced, while still providing a sufficiently widefield of view (e.g., a horizontal field of view). For example, the widthof the distal surface 706 of the gonioscopic optical element 704 can bereduced while still providing the same or similar field of view alongthe width of the image because of the demagnification. In some medicalconditions, the peripheral portion of the cornea can become hazy. Asmaller gonioscopic optical element 704 (e.g., which can still produce asufficiently large field of view) can be advantageous because it canenable imaging of the eye through a more central area of the cornea, andcan facilitate avoiding the peripheral portions of the cornea, which canbe hazy in some instances. Also, a smaller gonioscopic optical element704 can be less cumbersome to use, and/or can give the practitioner moveflexibility in positioning the gonioscope 700.

The gonioscope 700 can have one or more retention elements 744, whichcan be configured to engage tissue of the eye, such as scleral tissuearound the cornea, to retain the gonioscope 700 in positioned relativeto the eye. The one or more retention elements 744 can be positioned onthe distal side of one or more arms 746. The illustrated embodiment ofFIG. 36 has three arms 746, although any suitable number of arms can beused, such as one arm, two arms, four arms (e.g., one at each corner),five arms, six arms, etc. The one or more retention elements 744 and theone or more arms 746 can include features that are the same as, orsimilar to features of the retention elements and arms described in theWO 2016/154066 publication, which is incorporated herein by reference.

The gonioscope 700 can be used to create an optical fixation feature forthe subject to look at or focus on during use of the gonioscope 700,which can impede movement of the subject's eye relative to thegonioscope 700. The gonioscope 700 can include a light entry area orsurface 713 on a front of the gonioscope 700. Light for producing theoptical fixation feature can enter the gonioscope 700 through the lightentry surface 713. The light can then be redirected into the eye toproduce the optical fixation feature (e.g., a bright spot, shape,pattern, etc.). The light entry surface 713 can be positioned above theproximal surface 708 of the gonioscopic optical element 704. The lightentry surface 713 can be between the gonioscopic optical element 704 andthe handle 702, and/or between the gonioscopic optical element 704 andthe juncture area 732. The light entry surface 713 can be position in amiddle of the gonioscope 700 (e.g., equidistant between the right andleft sides). A plane down the middle of the gonioscope 700 dividing thegonioscope 700 into right and left sides (e.g., the plane of thecross-sectional view of FIG. 38) can extend through the light entrysurface 713. The light entry surface 713 can be on a protrusion thatextends from a front surface of the gonioscopic optical element 704,such as on or above the proximal surface 708. The light entry surface713 can be oriented to face towards a light source, such as a lightsource on a surgical microscope, although other light sources can beused in some implementations. The light entry surface 713 can have ashape of a circle, oval, square, polygon, or any other suitable shape.In some cases, the light entry surface 713 can be a portion (e.g., upperportion) of the proximal surface 708 of the gonioscopic optical element704. The light entry surface 713 can have a colored coating to transmitlight of a particular color (e.g. red, green or blue), to produce acolored optical fixation feature.

The gonioscope 700 can have a recess 715 formed on a back side of thegonioscope 700 (e.g., formed in the back side of the gonioscopic opticalelement 704). A surface of the recess 715 can redirect the light. Forexample, the recess 715 can have a base surface 717, which can be usedto redirect light (e.g., light that entered through the light entrysurface 713) into the eye to produce the optical fixation feature. Thebase surface 717 can reflect light by total internal reflection (TIR).The recess 715 can contain air or some other material having a lowerindex of refraction than the material of the gonioscopic optical element704. In some embodiments, the base surface 717 can have layer (e.g., acoating) of a material having a lower index of refraction than thematerial of the gonioscopic optical element 704. In some embodiments,the base surface 717 can have a reflective layer, such as a metallicmaterial, to facilitate reflection of light. In some cases, the basesurface 717 can have light scattering features and can redirect aportion of the light into the eye by scattering the light. At least aportion of the base surface 717 can be a diffuse surface. In some casesthe base surface 717 can be a frosted surface to diffuse or scatterlight.

The light entry surface 713 can be curved (e.g., concave or convex). Thelight entry surface 713 can be a lens. The light entry surface 713 canhave optical power. The light entry surface 713 can cause the lightentering the gonioscope 700 therethrough to converge, to diverge, toincrease or decrease in convergence, or to increase or decrease indivergence. The light entry surface 713 can have a spherical curvature.In some embodiments, an aspherical curvature, a paraboloidal curvature,or any other suitable curvature shape can be used to modify the lightentering the gonioscope 700.

With reference to FIG. 38, the light entry area or surface 713 can focusthe light onto a subset (e.g., a spot) of the base surface 717. Thelight (e.g., from a surgical microscope) can be diverging or collimated.The light entry surface 713 can have positive power to focus the light.The light can be reflected (e.g., by TIR) by the base surface 717 sothat the light is directed into the eye to be visible to the subject(e.g., as a bright spot). In some embodiments, the optical fixationfeature light directed into the eye by the gonioscope 700 can bediverging. In some cases the eye can focus the optical fixation featurelight onto the retina. With reference to FIG. 39, in some embodiments,the base surface 717 can be configured to scatter the light that isfocused at the spot or on the subset of the area of the base surface717. Some of the scattered light enters the eye and is visible to thesubject (e.g., as a spot that is less bright than the embodiment of FIG.38).

With reference to FIGS. 40A-C, the light entry area or surface 713 andthe light reflecting surface 717 can output optical fixation featurelight that is converging (as shown in FIG. 40A), collimated (as shown inFIG. 40B), or diverging (as shown in FIG. 40C). The light entry surface713 can cause the light entering the gonioscope 700 to converge, asshown in FIG. 40A. The converging light can be reflected by the basesurface 717, and the light can continue converging after beingreflected. The light can be focused on the retina of the eye. In somecases, the natural lens of the eye can also focus the light onto theretina to make an optical fixation feature visible to the subject. Withreference to FIG. 40B, in some embodiments the light entry surface 713can collimate the light entering the gonioscope 700. The light (e.g.,from a surgical microscope) can be diverging and the light entry surface713 can have optical power to reduce the divergence of the light as itenters the gonioscope 700. The collimated light can be reflected (e.g.,by TIR) by the base surface 717 and into the eye of the subject. Thenatural lens of the eye can focus the collimated light onto the retina.The light can be visible to the subject as it can be focused to a pointof light on the retina (e.g., as a bright spot). In some cases the sizeand/or brightness of the spot or other optical fixation feature candepend on the size of the light entry surface 713 that collimates thelight and/or the size of the surface 717 that reflects the light. Withreference to FIG. 40C, the light entry surface 713 can cause the lightentering the gonioscope 700 to diverge. The light (e.g., from a surgicalmicroscope) can be diverging, and the light entry surface 713 canincrease the divergence of the light, can permit the light to enter thegonioscope 700 without changing the divergence, or can decrease thedivergence of the light. The diverging light can be reflected by thebase surface 717 and can continue diverging as the light is directed tothe eye. In some cases, the natural lens of the eye can focus thediverging light onto the retina to produce an optical fixation featurevisible to the subject.

In some embodiments, the base surface 717 can modify the convergence ordivergence of the light. For example, the surface 717 can have a curved(e.g., aspherical) surface. The base surface 717 can have variousdifferent configurations to modify the light in different ways. The basesurface 717 can receive light that is converging, collimated, ordiverging and can be configured to output light towards the eye that isconverging, collimated, or diverging.

With reference to FIG. 41, in some embodiments, the base surface 717 canbe configured to scatter the light. Some of the scattered light entersthe eye and is visible to the subject (e.g., as a spot that is lessbright than the embodiments of FIG. 40A-C). In some cases, theembodiments of FIGS. 38, 39, and 41 can be less susceptible to alignmenterrors than the embodiment of FIG. 40A-C. In the embodiment of FIG. 41,the light entry surface 713 can cause light entering the gonioscope toconverge, collimate, or diverge, as discussed herein.

Many alternatives are possible. In some embodiments, the light entryarea or surface 713 can scatter light entering the gonioscope. The lightentry area can have surface diffusing features, a roughened surface, afrosted surface, etc. Some of the scattered light reaches the basesurface 717 and is reflected into the eye (e.g., by TIR or by areflective surface) to make a fixation feature visible to the subject.For example, a gonioscopic optical element similar to FIG. 4 can have areflective portion on a back surface 110 (e.g., a mirror coating) toreflect a portion of the scattered light into the eye to produce anoptical fixation feature visible to the subject. In some embodiments,diffused light can be reimaged by a curved surface 717 (e.g., anaspherical mirrored surface 717) to produce an optical fixation featurevisible to the subject. In some embodiments, the light entry surface 713can be configured to diverge (or increase divergence of) the lightentering the gonioscope, such as to distribute the light across the areaof the base surface 717. In some cases, the light entry surface 713 canpermit light to enter the gonioscope 700 without changing the divergenceor convergence of the light. The light entry surface 713 may have nooptical power, in some embodiments.

The gonioscope 700 can have a dedicated light entry surface 713 (e.g.,on a raised protrusion). With reference to FIG. 41, in some embodiments,a portion of the proximal surface 708 of the gonioscopic optical elementcan be used for the light entry area or surface 713. In someimplementations, the protrusion on the front of the gonioscope 700 canbe omitted. In some embodiments, the recess 715 on the back of thegonioscope 700 can be omitted, for example, as can be seen in FIG. 43. Aback surface of the gonioscope 700 (e.g., a back side of the gonioscopicoptical element 704) can be used as the surface 717 for reflectingand/or scattering light into the eye to produce the optical fixationfeature.

The configuration of the surface 717 can be used to produce differenttypes of optical fixation features. With reference to FIG. 44, a firstarea 719 (e.g., a center region) of the surface 717 can be configured todirect more light into the eye than a second area 721 (e.g., an outerregion). For example, the first area 719 can reflect light (e.g., by TIRor by a reflective surface), and the second area 721 can scatter light.Alternatively, the first area 719 of the surface 717 can be configuredto scatter light, and the second area 721 of the surface 717 can beconfigured to absorb light (e.g., having a dark material or lightfilter). Light can be sent to the surface 717, such as from the lightentry surface 713, such that light is distributed across at leastapportion of the first area 719 and at least a portion of the secondarea 721. In some cases the light can be distributed across the fullfirst area 719, the full second area 721, and/or the full surface 717.In some cases the light can be distributed across a majority of thefirst area 719, a majority of the second 721, and/or a majority of thesurface 717. In the embodiment of FIG. 44, the surface 717 can beconfigured to produce an optical fixation feature having the same of acircular spot. Any other suitable shape can be used. FIG. 45 shows asurface 717 configured to produce an optical fixation feature having theshape of a star. FIG. 46 shows a surface 717 configured to produce anoptical fixation feature having the shape of a bright ring with a dimmerarea inside the ring. A third area 723 (e.g., inside the ring) can beconfigured the same as the second area 721, or it can direct a thirddifferent amount of light into the eye. The subject can be instructed tolook at the center of the ring (which can be dimmer or dark). The centerof the ring can be the optical fixation point even though the center ofthe ring can be less bright than the ring, or can be a dark area insidethe ring. In some cases, it can easier for the subject to focus on adark or dimmer area than to focus on a bright spot or area. FIG. 47shows an example embodiment have four first areas 719 a-d configured todirect more light into the eye than a second area 721, which can havethe shape of a cross. Many other shapes can be used, such as a bull'seye, an arrow, etc. Each of the embodiments of FIGS. 44-47 can beinverted, so that the areas 719 direct less light in to the eye than theareas 721 or 723.

Many alternatives are possible. In some embodiments, the opticalfixation feature can be white light, or can include color (e.g., a redspot). Colored light can be used in some cases to produce a coloredoptical fixation feature. In some embodiments, the surface 717 and/orthe light entry surface 713 can have one or more color filters toproduce colored or multicolored light for the optical fixation feature.In some cases, the surface 717 can have a curved shape that produces ashape for the optical fixation feature. For example, the curvature ofthe surface 717 can reimage the light that impinges on the surface 717to produce a bright ring, with a dim center region inside the ring, orany other suitable shape. In some cases, ambient light can enter thegonioscope (e.g., through the light entry area or surface 713) toproduce the optical fixation feature. In some cases, the gonioscope caninclude a light source (e.g., a light emitting diode (LED)) and a powersupply (e.g., a battery) for powering the light source to produce theoptical fixation feature. The LED can be recessed into the gonioscopicoptical element 704 (e.g., in the recess 715) or the handle 702.Additional details regarding optical fixation feature embodiments aredisclosed in WO 2016/154066, which is incorporated herein by reference.

In some embodiments, the gonioscope 700 can include one or more markingsthat are visible in the image produced by the gonioscope 700. Themarkings can denote angles within the field of view of the image. Themarkings can divide the image by angle increments. For example, agonioscope can produce an image having a field of view of 6 clock hours(e.g., 180 degrees), and the markings can divide the image intoindividual clock hours (e.g., by angles of 30 degrees). The differentareas can be denoted by lines or different colors or any other suitablevisual features. With reference to FIG. 48, the distal surface 706 ofthe gonioscopic optical element 704 can have lines 725 a-f. When thegonioscope 700 of FIG. 48 is used to produce an image, the image canhave the lines 725 a-f, which can be similar to those shown in FIG. 50.The lines 725 a-f can be positioned on the distal surface 706, such thatwhen shown in the image the lines divide the field of view by angleincrements (e.g., by 30 degrees, or by 1 clock hour). More lines orfewer lines can be used, and the gonioscope can be configured to producea different image having a different field of view than shown in FIG.50. The markings (e.g., lines) can divide the field of view in the imageby angle increments of 5 degrees, 10 degrees, 15 degrees, 20 degrees, 25degrees, 30 degrees, 35 degrees, 40 degrees, 45 degrees, 50 degrees, 55degrees, 60 degrees, or any values therebetween, or any ranges boundedby any combination of these values, although other configurations arealso possible.

The lines 725 a-f can be burned (e.g., laser etched) into the gonioscope700 material (e.g., the distal surface 706). The lines 725 a-f can beetched into the gonioscope 700 material (e.g., the distal surface 706).The lines 725 a-f can be drawn onto the gonioscope 700 (e.g., the distalsurface 706). The lines 725 a-f can be an added layer (e.g., added ontothe distal surface 706). The lines 725 a-f can rough or frosted areas(e.g., on the distal surface 706), which can scatter light. The lines725 a-f can be made using air gaps.

FIG. 49 shows can example embodiment of a gonioscope 700 with markingsthat divide the field of view into areas 727 a-g. FIG. 51 shows theresulting image. The areas 727 a-g can have different light transmissionproperties so that the areas 727 a-g differ visibly. In some cases, eacharea can correspond to an angular range (e.g., one clock hour) of thefield of view of the image. The areas 727 a-g can be visually distinct,such as having different colors so that they can be differentiated inthe resulting image. The distal surface 706 of the gonioscopic opticalelement 704 can have a layer with different colors at different areas.In some cases, a different visual parameter (e.g., color) can be usedfor each of the areas 727 a-g, or two alternating visual parameters(e.g., colors) can be used. For example areas 727 a, 727 c, 727 e, and727 g can have a first visual parameter, such as a color filter coatingthat produces a red hue to the areas 727 a, 727 c, 727 e, and 727 g inthe resulting image. Areas 727 b, 727 d, and 727 f can have a secondvisual parameter, such as a color filter coating that produces a greenhue to the areas 727 b, 727 d, and 727 f in the resulting image. In somecases, one or more of the areas can be visually unmodified. For example,areas 727 b, 727 d, and 727 f can have no color filter or other visualmodifier, which can visually distinguish them from areas 727 a, 727 c,727 e, and 727 g that do have a visual modifier (e.g., a color filter).Adjacent areas can have different visual properties so that they can bedistinguished visually in the resulting image. In some embodiments, oneor more neutral density filters can be used to visually distinguishbetween adjacent areas. For example, areas 727 a, 727 c, 727 e, and 727g can have a neutral density filter while areas 727 b, 727 d, and 727 fdo not, which can produce an image that is darker at areas 727 a, 727 c,727 e, and 727 g than at areas 727 b, 727 d, and 727 f. Manyalternatives are possible. For example, in some embodiments, themarkings can be located so that they cover substantially only theportion of the image that corresponds to the trabecular meshwork, orother anatomical feature in the eye. In some embodiments, the markingscan be a grid. The markings can be used by a medical practitioner tomeasure or gauge distances in the eye. This can be particularly usefulwhen the image has magnification in one direction and demagnification inanother direction.

In some embodiments, the one or more markings can be positioned so thatthe one or more markings indicate where the pupil of the eye should belocated in the resulting image. FIG. 51A shows an example embodiment ofa gonioscope 700 having a marking (e.g. a line 729, or color region,etc.) that at least partially encircles the pupil of the eye as shown inFIG. 51B when the gonioscope 700 is positioned properly. This canprovide an indication to the practitioner that the angle of the eyeand/or gonioscope 700 is optimally positioned to view the trabecularmeshwork. The marking can be an arcuate line 729, a plurality ofconcentric lines which can correspond to different pupil sizes, aplurality of dots, arrows, or other markings along an arcuate pathconfigured to correspond with the pupil in the resulting image, asdiscussed herein. In some embodiments, the one or more markings (e.g.,line 727) corresponding to the pupil can be used together with themarkings indicating angles in the image (e.g., lines 725 a-f). Forexample, FIG. 51C shows can example embodiment having an arcuate line731 that is configured to align with the pupil of the eye in theresulting image, and lines 733 a-f that extend outward from the line 731to indicate angular regions in the resulting image. Various othercombinations of markings can be used.

Also, in FIG. 51C, the markings are positioned on the proximal surface708 of the gonioscopic optical element. Any of the markings discussedherein can be positioned on the proximal surface 708, or the distalsurface 706, or embedded in the gonioscopic optical element 704 (e.g.,between the proximal surface 708 and the distal surface 706. In somecases, markings on the distal surface 706 can be more focused in theimage viewed by the practitioner, because the distal surface 706 iscloser to the target structure than the proximal surface 708.Accordingly, it can be advantageous to have the one or more markings onthe distal surface 706. However, in some cases, it may be advantageousto have the one or more markings somewhat out of focus in the image seenby the practitioner, since this may make the markings less distractingwhile performing an implantation or other procedure. The one or moremarkings can be embedded in the gonioscopic optical element 704 by usingtwo gonioscopic optical element portions that are joined (e.g., glued,sonic welded, laser welded, etc.). The one or more markings can be onthe inside surface of one or both of the gonioscopic optical elementportions. The one or more markings can be formed by voids (e.g., airgaps) between the two portions. For example, one or more recesses,trenches, protrusions, or ridges can be formed in one or both of thegonioscopic optical element portions to form the one or more voids toproduce the one or more markings. In some embodiments, laser etching canbe used to produce one or more markings inside the gonioscopic opticalelement 704.

In some embodiments, the gonioscope 700 can be used with a support 750,which can be configured to support the gonioscope 700 during use. Insome cases, the support 750 can enable the gonioscope 700 to be usedhands-free, without the practitioner holding the handle 702 or otherwisetouching the gonioscope 700. The practitioner can hold the handle toposition the gonioscope 700, and once positioned with the supportengaged, the practitioner can release the handle 702. This can enablethe practitioner to use both hands for a procedure, and can also impedeunintended movement of the gonioscope 700, which can occur if thegonioscope 700 is held throughout a medical procedure. In someembodiments, the support 750 can be used even if the gonioscope 700 isbeing held. The support 750 can impede movement of the gonioscope 700relative to the eye. In some embodiments, the handle 702 can be omitted.

The support 750 can be made of a different material than the gonioscopicoptical element 704 and/or than the handle 702. The support 750 can bemade of a more flexible material than the gonioscopic optical element704 and/or than the handle 702. For example, the support 750 can be madeof a silicone material, a hydrogel material, or any other suitablematerial. The support 750 can be a separately formed from thegonioscopic optical element 704 and/or the handle 702. The support 750can be removably attachable to the gonioscope 700. The support 750 caninclude one or more engagement features that are configured to engagecorresponding engagement features on the gonioscope 700 to attach thesupport 750 to the gonioscope 700.

With reference to FIGS. 52 to 53, the support 750 can be configured toengage the handle 702 of the gonioscope 700. The support 750 can includea handle attachment 752. The handle attachment 752 can have a throughhole that is configured to receive the handle 702. The handle attachment752 can have an internal shape that generally corresponds to the outershape of the junction area 732, so that the handle attachment 752 canseat onto the junction area 732. The internal shape of the handleattachment 752 can be tapered (e.g., having a bottom opening larger thana top opening). The junction area 732 can be tapered (e.g., having alower area that is larger than an upper area). The taper of the handleattachment 752 can generally correspond to the taper of the junctionarea 732. The top of the handle 702 can be passed through the handleattachment 752, and the handle attachment 752 can slide down the handle702 until it seat with the junction area 732, the widening handle 702,and/or the gonioscopic optical element 704. Gravity and/or friction canimpede the handle attachment 752 from moving up the handle 702.

The support 750 can include one or more eye engagement structures thatare configured to engage one or more corresponding portions of the eyeto support the gonioscope 700. With reference to FIGS. 52 and 53, thesupport 750 can include a right flap 754 a and a left flap 754 b. Theright flap 754 a can be configured to engage a first eyelid (e.g., anupper eyelid or a lower eyelid), and the left flap 754 b can beconfigured to engage a second eyelid (e.g., the lower eyelid or theupper eyelid). The flaps 754 a-b can engage the upper or lower eyelidsrespectively, depending on the whether the gonioscope 700 is being usedwith the right or left eye, and/or depending on the orientation of thegonioscope 700. In some embodiments, a single flap can be used to engageonly one eyelid. A neck portion 756 can couple the handle attachment 752to the flaps 754 a-b. The neck portion 756 can extend downward (e.g.,distally) from a back side of the handle attachment 752. The flaps 754a-b can extend from the right and left sides of the distal end of theneck portion 756. The neck portion 756 can extend along the back side ofthe gonioscopic optical element 704. The neck portion 756 can beflexible. When in use, the neck portion 756 can flex (e.g., in thedirection of arrow 758 in FIG. 52) so that flaps 754 a-b lay against theeye. The flaps 754 a-b can have a distal side 760 that faces towards theeye (e.g., downward) and a proximal side 762 that faces away from theeye (e.g., upward), when in use. The distal side 760 can contact thesclera of the eye. The flaps 754 a-b can engage anatomy adjacent the eyeof the subject. The flaps 754 a-b can fit between the eye and therespective eyelids. The eyelid can press down on the flap 754 a or 754 bto hold the support 750 against the eye. The proximal surface 762 caninclude texture, such as bumps, recesses, protrusions, ridges, cleats,and the like, to engage the underside of the eyelid. The distal surface760 can include texture, such as, recesses, protrusions, ridges, cleats,and the like, to engage the tissue of the eye (e.g., the sclera). Thesupport 750 can press the gonioscope against the eye, which can causethe retention elements 744 to engage the eye tissue (e.g., the sclera).Thus the support 750 and the retention elements 744 can work together tohold the gonioscope 700 onto the eye.

With reference to FIGS. 54 and 55, the support 750 can be configured toengage an arm 746 of the gonioscope 700. The gonioscope 700 can have anarm 746 extending from a back side of the gonioscopic optical element704. The arm 746 can have one or more retention elements 744, asdiscussed herein. The support 750 can include an arm attachment 764. Thearm attachment 764 can have a recess configured to receive the arm 746therein. The arm 746 can be inserted into the recess to couple thesupport 750 to the gonioscope 700. Friction can hold the arm 746 in therecess during use. The retention elements 744 can engage the material ofthe support 750 to facilitate the coupling. The support 750 of FIGS. 54and 55 can have flaps 754 a-b similar to the embodiment of FIGS. 52 and53.

With reference to FIGS. 56 and 57, the support 750 can engage a cornerof the eye (e.g., at or near the punctum). The support 750 can have aflap 766, with a distal surface 768, and a proximal surface 770. Theflap 766 can be flexible. When in use, the flap 766 can flex back andupward (e.g., similar to the flexible neck 756 discussed in connectionwith FIG. 52). The flap 766 can fit between the eye and the anatomyadjacent the eye. For example, the flap 766 can slide under one or bothof the upper eyelid and the lower eyelid. The flap 766 can fit betweenthe eye and the canthus, the puntum, or other structure adjacent theeye. The flap 766 can have a distal side 768 that faces towards the eye(e.g., downward) and a proximal side 770 that faces away from the eye(e.g., upward), when in use. The distal side 768 can contact the scleraof the eye. The proximal surface 770 can include texture, such as bumps,recesses, protrusions, ridges, cleats, and the like, to engage theunderside of the structure adjacent the eye. The distal surface 768 caninclude texture, such as, recesses, protrusions, ridges, cleats, and thelike, to engage the tissue of the eye (e.g., the sclera). FIGS. 56 and57 show the support 750 attached using an arm attachment 764, althoughany suitable type of attachment can be used.

With reference to FIGS. 58 and 59, in some embodiments, the support 750can engage the recess 715. The support 750 can have a protrusion 772that is shaped to press fit into the recess 715. The protrusion 772 canhave a shape that generally conforms to the shape of the recess 715(e.g., a cylinder). In some cases, the protrusion 772 can be slightlylarger than the recess and can be flexible so that the protrusiondeforms (e.g., compresses) when it is inserted into the recess 715. Therecess 715 can be deeper than the protrusion 772, so that when theprotrusion 772 is fully inserted into the recess 715 there is still anair gap between the protrusion 772 and the base surface 717 (e.g., tofacilitate TIR as discussed herein). The support 750 can have a neck758, which can be flexible as discussed herein. The support 750 of FIGS.54 and 55 can have flaps 754 a-b similar to the embodiment of FIGS. 52and 53.

FIG. 59A is a perspective view of an example embodiment of a support 750for use with a gonioscope. FIG. 59B is a bottom-front perspective viewof the support 750 coupled to a gonioscope 700. FIG. 59C is a top-rearperspective view of the support 750 coupled to the gonioscope 700. Thesupport 750 of FIG. 59A can be similar to the embodiment of FIGS. 56 and57, although features of any of the supports disclosed herein can beused combined or interchanged. The support 750 can include a recess 774,which can be configured to receive an arm 746 of the gonioscope 700,such as the back arm that extends from the back side of the gonioscopicoptical element 704. The inner surface of the recess 744 can begenerally sized and shaped to correspond to the outer surface of the arm746. The support 750 can have an opening 776 configured to align withone or more retention elements 744 on the arm 746 when the arm 746 isinserted into the recess 774. The one or more retention elements 744 canextend into or through the opening 776. The engagement between the oneor more retention elements 744 and the opening 776 can hold the support750 onto the arm 746. Also, when placed on the eye, the opening 776 canpermit the retention elements 744 to engage the eye (e.g. the sclera) asdescribed herein.

The support 750 can include a back wall 778 that is configured to extendup a portion of the back side of the gonioscope 700 when the support 750is attached thereto (as can be seen in FIG. 59C). The support 750 canengage a corner of the eye. The support 750 can have a flap 766, with adistal surface 768, and a proximal surface 770. The flap 766 can beflexible. When in use, the flap 766 can flex back and upward. The flap766 can fit between the eye and the anatomy adjacent the eye. The flap766 can fit between the eye and the canthus, the puntum, or otherstructure adjacent the eye. The flap 766 can have a tapered or pointedend to facilitate the flap 766 engaging the corner of the eye. The flap766 can have a distal side 768 that faces towards the eye (e.g.,downward) and a proximal side 770 that faces away from the eye (e.g.,upward), when in use. The distal side 768 can contact the sclera of theeye. The proximal surface 770 can include texture 780, such as bumps,recesses, protrusions, ridges, cleats, and the like, to engage theunderside of the structure adjacent the eye. The distal surface 768 caninclude texture, such as, recesses, protrusions, ridges, cleats, and thelike, to engage the tissue of the eye (e.g., the sclera).

FIG. 59D is a bottom-front perspective view of another exampleembodiment of a support 750, shown coupled to a gonioscope 700. FIG. 59Eis a top-rear perspective few of the support 750 coupled to thegonioscope 700. The support 750 can attach to an arm 746 of thegonioscope 700, similar to the discussion regarding FIGS. 59A-C,although any suitable attachment mechanism or manner can be used. Thesupport 750 can include a recess 774, which can be configured to receivean arm 746 of the gonioscope 700. The support 750 can have an opening776 configured to align with one or more retention elements 744 on thearm 746 when the arm 746 is inserted into the recess 774. The support750 can include a back wall 778 that is configured to extend up aportion of the back side of the gonioscope 700 when the support 750 isattached thereto.

The support 750 can include flaps or wings, such as a right wing or flap754 a and a left wing or flap 754 b, a shown in FIGS. 59D and 59E. Theright flap 754 a can be configured to engage a first eyelid (e.g., anupper eyelid or a lower eyelid), and the left flap 754 b can beconfigured to engage a second eyelid (e.g., the lower eyelid or theupper eyelid). The flaps 754 a-b can engage the upper or lower eyelidsrespectively, depending on the whether the gonioscope 700 is being usedwith the right or left eye, and/or depending on the orientation of thegonioscope 700. In some embodiments, a single flap can be used to engageonly one eyelid. The support 750 can have a neck portion 756 that can beflexible. When in use, the neck portion 756 can flex (e.g., rearwardand/or upward) so that flaps 754 a-b lay against the eye. Either or bothof the flaps 754 a-b can have a distal side 760 that faces towards theeye (e.g., downward) and a proximal side 762 that faces away from theeye (e.g., upward), when in use. The distal side 760 can contact thesclera of the eye. The flaps 754 a-b can engage anatomy adjacent the eyeof the subject. The flaps 754 a-b can fit between the eye and therespective eyelids. The eyelid can press down on the flap 754 a or 754 bto hold the support 750 against the eye. The proximal surface 762 caninclude texture 780, such as bumps, recesses, protrusions, ridges,cleats, and the like, to engage the underside of the eyelid. The distalsurface 760 can include texture (not shown), such as, recesses,protrusions, ridges, cleats, and the like, to engage the tissue of theeye (e.g., the sclera).

The attachment mechanisms and other features of the supports 750 ofFIGS. 52 to 59E can be interchanged and/or combined. For example, asupport 750 can include a handle attachment 752 (e.g., similar to FIG.52) and an arm attachment 764 (e.g., similar to FIG. 54). A support 750can have a handle attachment 752 and a protrusion 772 for engaging arecess 715 (e.g., similar to FIGS. 58 and 59). A support 750 can have anarm attachment 764 and a protrusion 772 for engaging a recess 715. Asupport 750 can have a handle attachment 752, an arm attachment 764, anda protrusion 772 for engaging a recess 715. Any suitable attachmentmechanism can be used to couple the support 750 to the gonioscope 700.The support 750 can be adhered to the gonioscope 700, over molded ontothe gonioscope 700, secured to the gonioscope 700 by a separatefastener, sonically welded, etc. The supports 750 disclosed herein canbe used with any gonioscope embodiment disclosed herein. Any suitablestructure can be used to engage the anatomy of the subject to providesupport for the gonioscope 700.

Any of the gonioscopes disclosed herein can include retention elementsfor impeding movement of the gonioscope relative to the eye. Thegonioscope 700 can have retention elements 744, which can be an integralpart of the gonioscope 700. The retention elements 744 can be integrallyformed with the gonioscopic optical element 704 and/or the handle 702.The retention elements 744 can be made of the same material as thegonioscopic optical element 704 and/or the handle 702. The gonioscope700 can include a plurality of retention elements 744 coupled to thegonioscopic optical element 704 and configured to engage an eye toretain the gonioscope 700 relative to the eye, similar to the otherretention element embodiments disclosed herein. The plurality ofretention elements 744 can be stationary relative to the gonioscopicoptical element 704. Any of the various types of retention elements 744disclosed herein can be used for the gonioscope 700, or any of the othergonioscopes disclosed herein. For example, the gonioscope 700 caninclude one or more arms 746 with one or more retention elements 744 ondistal portions of the arms 746. In some embodiments, the arms 746 canextend from the gonioscopic optical element 704. The arms 746 can extenddistally, and in some cases can extend distally past the distal surface706 of the gonioscopic optical element 704. The arms 746 can extendradially outward. The retention elements 744 can be configured to engagethe sclera of the eye and can be configured to not contact the cornea.The retention elements 744 can be configured to restrain movement of theeye relative to the gonioscope 700. The retention elements 744 can beconfigured to orient the gonioscopic optical element 704 relative to theeye to facilitate viewing into the eye.

The retention elements 744 can be located on the distal side of thegonioscope 700. For example, the retention elements 744 can be adjacentto the distal surface 706. The retention elements 744 can be configuredto contact certain portions of the patient's eye, while avoiding contactwith other portions. For example, the retention elements 744 can beconfigured to contact the sclera and/or conjunctival tissue, whileavoiding contact with the cornea. The retention elements 744 can beconfigured to contact the sclera of the eye when the gonioscope 700 ispositioned for viewing an anterior chamber of the eye. The retentionelements 744 can be configured to not contact the cornea of the eye whenthe gonioscope 700 is positioned for viewing an anterior chamber of theeye. The retention elements 744 can comprise atraumatic structures. Theretention elements 744 can comprise a multi-point contact structure withmultiple contact points configured to be distributed around the eye,such as on the area surrounding the cornea. The retention elements 744can have minimal contact surface area, in some cases.

The retention elements 744 and/or the arms 746 can be made of the samematerial as the gonioscopic optical element 704, and can be integrallyformed therewith. In some embodiments, the gonioscopic optical element704 and the retention elements 744 can comprise different materials. Forexample, the gonioscopic optical element 704 can comprise a glass orplastic material, while the retention elements 744 can comprise atextile, cloth, or fabric material. Various other materials can be usedfor the retention elements 744, in some implementations, such as metalor ceramic materials. The user can place the gonioscope 700 on asubject's eye 100. The retention elements 744 can engage the eye toretain the gonioscope 700 relative to the eye.

The retention elements 744 can be disposed on a generally circular path.The retention elements 744 can be disposed on a generally circular paththat can have a circumference larger than the circumference of thecornea, such that the retention elements 744 do not contact the corneaduring clinical use. The outer circumference of the retention elements744 can avoid contacting the lid speculum. By way of example, theretention elements 744 can be disposed on a generally circular path thathas a diameter that is at least about 10 mm, at least about 11 mm, atleast about 12 mm, at least about 13 mm, at least about 14 mm, or atleast about 15 mm, or any value or ranges therebetween, although valuesoutside these ranges can be used in some implementations. In someembodiments, the retention elements 744 can be disposed on a generallycircular path that has a diameter that is less than or equal to about 20mm, less than or equal to about 15 mm, less than or equal to about 14mm, less than or equal to about 13 mm, or less than or equal to about 12mm, or any values or ranges therebetween, although values outside theseranges can be used in some implementations.

The retention elements 744 can be positioned to be distributed aroundthe gonioscope across a circumferential angle of at least about 220degrees, at least about 230 degrees, at least about 250 degrees, atleast about 270 degrees, at least about 290 degrees, or more. Forexample, the one or more arms 746 can be positioned to distribute theretention elements 744 around the gonioscope 700 across thecircumferential angle. In some embodiments, the retention elements 744can be positioned to be distributed around the gonioscope 744 across acircumferential angle of less than or equal to about 320 degrees, lessthan or equal to about 310 degrees, less than or equal to about 290degrees, less than or equal to about 270 degrees, less than or equal toabout 250 degrees, or less. In some embodiments, the retention elements744 can be positioned to be distributed around the gonioscope across acircumferential angle of about 270 degrees. The retention elements 744can be positioned to be distributed around the gonioscope such that eachgap between adjacent retention elements has a circumferential angle thatis less than or equal to about 145 degrees, less than or equal to about135 degrees, less than or equal to about 120 degrees, less than or equalto about 105 degrees, less than or equal to about 90 degrees, less thanor equal to about 75 degrees, less than or equal to about 60 degrees, orless. The retention elements 744 can be positioned to be distributedaround the gonioscope such that at least one of the gaps betweenadjacent retention elements has a circumferential angle that is at leastabout 60 degrees, at least about 75 degrees, at least about 90 degrees,at least about 105 degrees, at least about 120 degrees, or more. Theretention elements 744 can be distributed to restrain movement of thegonioscope 700 relative to the eye in various different directions.

The plurality of retention elements 744 can be configured to engage theeye without causing trauma to the eye. The retention elements 744 can beatraumatic, and can comprise an atraumatic shape. The atraumaticretention elements 744 can have a shape that is sufficiently blunt thatthe retention elements 744 do not pierce or cause other trauma to theeye when pressed against the eye (e.g., against the sclera) duringclinical use, while also restraining movement between the eye and thegonioscope 700. For example, the atraumatic retention elements 744 caninclude protrusions that can be pressed against the tissue of the eye(e.g., the sclera) to deform the tissue of the eye without piercing intothe tissue of the eye. The retention element structures that areconfigured to engage the eye can have a minimum radius of curvature ofabout 0.002 inches or more, of about 0.003 inches or more, of about0.004 inches or more, of about 0.005 inches or more, of about 0.007inches or more, of about 0.009 inches or more, of about 0.01 inches ormore, or of about 0.012 inches or more. The retention element structuresthat are configured to engage the eye can have at least a portion with aradius of curvature that is less than or equal to about 0.02 inches,less than or equal to about 0.015 inches, less than or equal to about0.012 inches, less than or equal to about 0.01 inches, less than orequal to about 0.009 inches, less than or equal to about 0.008 inches,less than or equal to about 0.007 inches, less than or equal to about0.006 inches, or less than or equal to about 0.0057 inches. Valuesoutside these ranges can be used for the radii of curvature on theretention elements, in some implementations.

The retention elements 744 shown and described herein can have variousdifferent shapes. The retention elements 744 can include generallyV-shaped retention elements. In some embodiments, retention elementshaving different shapes can be used on one gonioscope. The retentionelements 744 can be one or more ridges (e.g., parallel or V-shaped), oneor more cleats, etc. The retention elements 744 can have a generallyfrustoconical shape. Various different numbers of retention elements744. For example, each of the arms 746 (or any other suitable locationon the gonioscope 700) can have one, two, three, four, five, six, eight,ten, fifteen, twenty retention elements 744, or more or any rangebounded by any of the values listed above.

Intraoperative eye movement of a patient can be reduced or restrained bythe patient. In some embodiments, a gonioscope can include a fixationpoint or feature that is visible to the patient. For example, apractitioner can instruct a patient to gaze at a certain fixation pointto restrain eye movement. A gonioscope optical element can be configuredto produce an optical fixation point. The optical fixation point can belocated in the optical path of a patient. Optical fixation points can beused to help a patient orient their eye to align with the gonioscopicoptical element and/or a microscope. The fixation point can be used withthe gonioscopes described herein during procedures and treatments suchas, for example, glaucoma surgery (e.g., minimally invasive glaucomasurgery (MIGS), laser trabeculoplasty (e.g., SLT/ALT), fundus laser,vitrectomy laser, and suture lysis optics where ocular retention andeye/lens stabilization would be beneficial. The fixation point can beactively illuminated (e.g., by an LED) or passively illuminated (e.g.,with light emitted from a microscope light or ambient light). Multiplefixation points differentiated via color and/or shape may allow a user,such as a physician or other medical practitioner, to further refine thepatient's eye orientation. An optical fixation point can be used toorient the eye of the patient. Multiple optical fixation points can beused to further help orient the eye to the gonioscopic optical element.

FIGS. 60A to 60E are schematic drawings of different views of someexample embodiments of a optical fixation point used with a gonioscopicoptical element, which can be applied to any of the embodimentsdisclosed herein. The gonioscopic optical element 928 can comprise aproximal surface 928A and a distal surface 928B. In some embodiments,the gonioscopic optical element 928 can include a thick side 928C, and athin side 928D. The optical fixation point 960 can be configured to bevisible to the subject when the gonioscope is positioned on the eye. Theoptical fixation point 960 can be located on the thick side 928C of thegonioscopic optical element 928. The location of the optical fixationpoint 960 can be configured to provide a desired viewing angle (e.g.,for a medical practitioner to use in examining and/or operating on thepatient's eye). For example, the location of the optical fixation point960 can be such that when a patient looks directly at the opticalfixation point 960, the medical practitioner can view a desiredstructure of the inside of the eye (e.g., the anterior chamber angle)through the proximal surface of the gonioscopic optical element 928.

As shown in FIG. 60A, the optical fixation point 960 can be implementedusing a light source. For example, the optical fixation point 960 canmade using a light emitting diode (LED), although other types of lightsources can also be used. The gonioscope can include a power source,such as a battery, which can be contained in or on the handle of thegonioscope, or any other suitable location. The power source can provideelectrical power to one or more light sources to provide one or morefixation elements. The optical fixation point 960 can be activelyilluminated. In some embodiments, the gonioscopic optical element 928can include a recess (e.g., on the thick side 928C, as shown in FIG.9A), and the light source can be at least partially disposed in therecess.

As shown in FIG. 60B, an optical fixation point can include multiplefixation points 960A, 960B, 960C. In one embodiment, the multiplefixation points can comprise a first fixation point 960A, a secondfixation point 960B, and a third fixation point 960C. The multiplefixation points 960A-C can be made using different light sources,similar to the description of the fixation point 960 in connection withFIG. 60A. The multiple fixation points 960A, 960B, 960C can be alignedalong a linear path, although other special arrangements can be useddepending on the desired orientation of the gonioscope relative to theeye. For example, when the eye is focused on a first fixation point960A, the gonioscopic optical element 928 can be oriented relative tothe eye to facilitate viewing a first structure or area in the eye, andwhen the eye is focused on the second fixation point 960B, thegonioscopic optical element 928 can be oriented relative to the eye tofacilitate viewing a second structure or area in the eye. A thirdfixation point 960C can similarly be used to facilitate viewing a thirdstructure or area in the eye, and additional fixation points can be usedto facilitate viewing still additional structures or areas in the eye.The multiple fixation points 960A, 960B, 960C can comprise differentappearances and different locations. For example, as shown in FIG. 60C,the first point 960A can comprise a circular shape, the second point960B can comprise a star-shape, and the third point 960C can comprise atriangular shape, although various different shapes and otherappearances can be used. In some embodiments, the different fixationpoints can have different colors. The multiple fixation points 960A,960B, 960C can comprise one or more fixation points configured to beselectively illuminated. In some embodiments, the gonioscope can includeone or more user input elements (e.g., one or more buttons or switches)configured to receive input from the user for controlling the selectiveillumination of the multiple fixation points 960A-C. For example, a usercan illuminate a first fixation point 960A, while the one or moreadditional fixation point 960B and 960C are not illuminated. By thismanner the user can direct the subject's vision to the illuminatedfixation point 960A to facilitate proper orientation of the eye.

The optical fixation point can comprise a light pipe, in someembodiments. FIGS. 60D and 60E schematically show side and bottom viewsof different example embodiments of gonioscopic optical elements thatinclude light pipes. The gonioscopic light pipes 964A, 964B, 964C can beconfigured to receive a light from the microscope 968 or other suitablelight source (e.g., ambient light). The gonioscopic light pipes 964A,964B, 964C can be configured to redirect light from the microscope 968to the patient's eye, to be visible to the patient as a fixationfeature. In some embodiments, the receiving end of the light pipe thatreceives light (e.g., light 968 from the microscope) can be larger thanan exit end. The light pipe can be tapered from the receiving end to theexit end, for example to produce a small, bright fixation point 966A,966B, and 966C for the patient to view.

In some embodiments, the light pipe 964B can be disposed at leastpartially inside the gonioscopic optical element. For example, thegonioscopic optical element can be overmolded around the light pipe964B, or the light pipe can be inserted into a recess that is formed inthe gonioscopic optical element. In some embodiments, the lightreceiving end of the light pipe can be exposed (e.g., on the proximalend of the gonioscopic optical element) to receive light into the lightpipe 964B. A majority of the light pipe 964B can be disposed inside thegonioscopic optical element.

The light pipes 964A, 964B, 964C can be disposed partially or completelyoutside the gonioscopic optical element. The light receiving end of thelight pipe 964B can be outside the gonioscopic optical element. Thelight pipe 964A can be outside the gonioscopic optical element anddisposed directly adjacent and in contact with the gonioscopic opticalelement (e.g., on the thick side of the gonioscopic optical element).The light pipe 964C can be disposed outside and spaced apart from thegonioscopic optical element (e.g., on the thick side of the gonioscopicoptical element). An air gap can be disposed between the gonioscopicoptical element and the light pipe 964C, and the air gap can facilitatethe propagation of light in the light pipe by total internal reflection.In some embodiments, a majority of the light pipe can be disposedoutside the gonioscopic optical element, and in some cases a portion ofthe light pipe 964C (e.g., the light exit portion) can extend into thegonioscopic optical element (e.g., into a recess formed therein). Insome embodiments, the light exit portion of the light pipe 964A can bedisposed outside the gonioscopic optical element, and a feature (e.g., arecess) on the gonioscopic optical element can be configured to receivelight emitted from the light exit portion to direct the light to the eyeto provide the fixation point 966A. The light pipe 964A and 964B can begenerally linear, or the light pipe 964 can include one or more turns todirect the light to form the fixation point 966A-C. In some embodiments,the material of the light pipe 964A-C can have a higher refractive indexthan the material of the gonioscopic optical element, to facilitatepropagation of light in the light pipe by total internal reflection. Thegonioscopic optical element can be configured to act as a claddingmaterial on at least a portion of the outside of the light pipe 964A-C.In some embodiments, a reflective coating can be disposed on the outsideof the light pipe 964A-C. The reflective coating can facilitate thepropagation of light and/or can provide a separation from the maingonioscopic optical element 928.

With reference to FIG. 60F, in some embodiments, the gonioscopic opticalelement 928 can include a light guide 964D that is formed by one or moremirrored or reflective surfaces. The gonioscopic optical element 928 caninclude a recess (e.g., extending from the proximal surface 928A intothe body of the gonioscopic optical element 928). One or more surfacesof the recess can be reflective to guide light along the recess (e.g.,to create a fixation point 966D). In some embodiments, the sides of therecess can have a metallic coating or other reflective material thereon,and a bottom portion of the recess does not include the reflectivematerial such that the light is reflected off the sides of the recessuntil the light reaches the bottom portion of the recess, where thelight exits the recess and enters the material of the gonioscopicoptical element 928 to be visible to a patient as an optical fixationpoint 966D. In some cases, the recess can be filled with a higher indexmaterial than the surrounding material and light can be reflected bytotal internal reflection. The light can propagate from the bottomportion of the recess, through the material of the gonioscopic opticalelement, to the distal surface 928B, in order to be visible to the eyeof the patient. In some embodiments, the recess can be tapered having alarger width at the top and a narrower width at the bottom portion, suchthat the light guided down along the recess can be concentrated at thebottom portion of the recess. The recess can have a generally conicalshape (e.g., a conical or frastoconical shape). The recess can have agenerally circular, round, or oval cross-sectional shape, or a generallysquared, rectangular, or polygonal cross-sectional shape.

Many variations are possible. For example, in some embodiments, thefixation point 960, 1060 can be a colored dot, an ink dot, a coloredobject, etc., which can be suspended inside the gonioscopic opticalelement or disposed on an outside surface of the gonioscopic opticalelement. The various embodiments disclosed regarding gonioscopes thatinclude one or more fixation points can be used together with theembodiments disclosed herein with regards to the retention elements. Forexample, a gonioscope having one or more fixation points as shown ordiscussed in connection with any of the embodiments disclosed herein.

Unless the context clearly requires otherwise, throughout thedescription and the claims, the words “comprise,” “comprising,”“include,” “including,” and the like are to be construed in an inclusivesense, as opposed to an exclusive or exhaustive sense, such as in thesense of “including, but not limited to.” The words “coupled” or“connected”, as generally used herein, refer to two or more elementsthat can be either directly connected, or connected by way of one ormore intermediate elements. Additionally, the words “herein,” “above,”“below,” and words of similar import, when used in this application,shall refer to this application as a whole and not to any particularportions of this application. Where the context permits, words in theDetailed Description using the singular or plural number can alsoinclude the plural or singular number, respectively. The words “or” inreference to a list of two or more items, is intended to cover all ofthe following interpretations of the word: any of the items in the list,all of the items in the list, and any combination of the items in thelist. The words “and/or” is also intended to cover all of the followinginterpretations of the word: any of the items in the list, all of theitems in the list, and any combination of the items in the list. Theterm “based on,” as generally used herein, encompasses the followinginterpretations of the term: solely based on or based at least partlyon. All numerical values provided herein are intended to include similarvalues within a measurement error.

Moreover, conditional language used herein, such as, among others,“can,” “could,” “might,” “may,” “e.g.,” “for example,” “such as” and thelike, unless specifically stated otherwise, or otherwise understoodwithin the context as used, is generally intended to convey that certainembodiments include, while other embodiments do not include, certainfeatures, elements and/or states.

The various features and processes described above may be usedindependently of one another, or may be combined in various ways. Allpossible combinations and subcombinations are intended to fall withinthe scope of this disclosure. In addition, certain method or processelements may be omitted in some implementations. The methods andprocesses described herein are also not limited to any particularsequence, and any blocks or states relating thereto can be performed inother sequences that are appropriate. For example, any described blocksor states may be performed in an order other than that specificallydisclosed, or multiple blocks or states may be combined in a singleblock or state. The example blocks or states may be performed in serial,in parallel, or in some other manner. Blocks or states may be added toor removed from the disclosed example embodiments. The example systemsand components described herein may be configured differently thandescribed. For example, elements may be added to, removed from, orrearranged compared to the disclosed example embodiments.

The teachings of the embodiments provided herein can be applied to othersystems, not necessarily the systems described above. The elements andacts of the various embodiments described above can be combined toprovide further embodiments.

While certain embodiments have been described, these embodiments havebeen presented by way of example only, and are not intended to limit thescope of the disclosure. Indeed, the novel methods and systems describedherein can be embodied in a variety of other forms. Furthermore, variousomissions, substitutions and changes in the form of the methods andsystems described herein can be made without departing from the spiritof the disclosure. The accompanying claims and their equivalents areintended to cover some such forms or modifications as would fall withinthe scope and spirit of the disclosure.

The following is claimed:
 1. A gonioscope comprising: a gonioscopicoptical element made of transparent material and comprising: a curveddistal contact surface that is concave and configured to contact asurface of an eye of a subject; a curved proximal surface comprising: aviewing portion that is configured to receive light from structureinside the eye through the distal contact surface and to output thelight through the viewing portion of the proximal surface to form animage of the structure inside the eye; and a light diffusing portionpositioned above the viewing portion, the light diffusing portionconfigured to diffuse light that passes through the light diffusingportion so that at least a portion of the diffused light illuminates thestructure inside the eye; wherein the proximal surface is convex along afirst direction to provide magnification along a first direction of theimage, and wherein the proximal surface is concave along a seconddirection to provide demagnification along a second direction of theimage; and a recess at a front side of the gonioscope, the recess formedby an intersection of the curved distal surface and the curved proximalsurface; and a handle coupled to the gonioscopic optical element.
 2. Thegonioscope of claim 1, wherein the recess has a width of at least about7 mm.
 3. The gonioscope of claim 2, wherein the recess has a width ofless than or equal to about 15 mm.
 4. The gonioscope of claim 1, whereinthe recess has a width between about 10 mm and 15 mm.
 5. The gonioscopeof claim 1, wherein the light diffusing portion comprises surfacediffusing features.
 6. The gonioscope of claim 1, wherein the lightdiffusing portion comprises embedded diffusing features.
 7. Thegonioscope of claim 1, wherein the second direction is orthogonal to thefirst direction.
 8. The gonioscope of claim 1, wherein the handle has anelliptical cross-sectional shape with a major axis that is longer than aminor axis.
 9. The gonioscope of claim 1, wherein the handle isambidextrous and extends upward along a center plane that divides thegonioscopic optical element into a right side and a left side.
 10. Thegonioscope of claim 1, wherein the handle and the gonioscopic opticalelement are integrally formed of the same material.
 11. A gonioscopecomprising: a gonioscopic optical element made of transparent materialand comprising: a distal contact surface that is concave and configuredto contact a surface of an eye of a subject; and a proximal surface,wherein the gonioscopic optical element is configured to receive lightfrom structure inside the eye through the distal contact surface and tooutput the light through the proximal surface to form an image of thestructure inside the eye, wherein the proximal surface is convex along afirst direction to provide magnification along a first direction of theimage, and wherein the proximal surface is concave along a seconddirection to provide demagnification along a second direction of theimage, wherein the magnification is between about 1.1× and about 1.5×and wherein the demagnification is between about 0.95× and about 0.75×;and a handle coupled to the gonioscopic optical element.
 12. Thegonioscope of claim 11, wherein the second direction is orthogonal tothe first direction.
 13. The gonioscope of claim 11, wherein themagnification is between about 1.2× and about 1.4× and wherein thedemagnification is between about 0.9× and about 0.8×.
 14. The gonioscopeof claim 11, wherein the proximal surface comprises: a viewing portionthat is configured to form the image of the structure inside the eye;and a light diffusing portion positioned above the viewing portion, thelight diffusing portion configured to diffuse light that passes throughthe light diffusing portion.
 15. The gonioscope of claim 11, wherein thehandle is ambidextrous and extends upward along a center plane thatdivides the gonioscopic optical element into a right side and a leftside.
 16. The gonioscope of claim 11, wherein the gonioscopic opticalelement comprises markings that are visible in the image.
 17. Thegonioscope of claim 11, wherein the gonioscope comprises one or moreretention elements configured to engage tissue of the eye to retain thegonioscope in position on the eye.
 18. The gonioscope of claim 17,wherein the one or more retention elements are positioned on one or morearms that extend from the gonioscopic optical element.
 19. Thegonioscope of claim 11, further comprising a flexible eye engagementfeature removably attachable to the gonioscopic optical element, the eyeengagement feature configured to engage between the eye and ananatomical structure adjacent the eye to support the gonioscope.
 20. Agonioscope comprising: a gonioscopic optical element made of transparentmaterial and comprising: a distal contact surface that is concave andconfigured to contact a surface of an eye of a subject; and a proximalsurface, wherein the gonioscopic optical element is configured toreceive light from structure inside the eye through the distal contactsurface and to output the light through the proximal surface to form animage of the structure inside the eye, wherein the proximal surface isconvex along a first direction to provide magnification along a firstdirection of the image, wherein the proximal surface is concave along asecond direction to provide demagnification along a second direction ofthe image, and wherein the proximal surface comprises: a viewing portionthat is configured to form the image of the structure inside the eye;and a light diffusing portion positioned above the viewing portion, thelight diffusing portion configured to diffuse light that passes throughthe light diffusing portion; and a handle coupled to the gonioscopicoptical element.
 21. The gonioscope of claim 20, wherein the seconddirection is orthogonal to the first direction.
 22. A gonioscopecomprising: a gonioscopic optical element made of transparent materialand comprising: a distal contact surface that is concave and configuredto contact a surface of an eye of a subject; and a proximal surface,wherein the gonioscopic optical element is configured to receive lightfrom structure inside the eye through the distal contact surface and tooutput the light through the proximal surface to form an image of thestructure inside the eye, wherein the proximal surface is convex along afirst direction to provide magnification along a first direction of theimage, and wherein the proximal surface is concave along a seconddirection to provide demagnification along a second direction of theimage; and a handle coupled to the gonioscopic optical element, whereinthe handle is ambidextrous and extends upward along a center plane thatdivides the gonioscopic optical element into a right side and a leftside.
 23. The gonioscope of claim 22, wherein the second direction isorthogonal to the first direction.
 24. A gonioscope comprising: agonioscopic optical element made of transparent material and comprising:a distal contact surface that is concave and configured to contact asurface of an eye of a subject; and a proximal surface, wherein thegonioscopic optical element is configured to receive light fromstructure inside the eye through the distal contact surface and tooutput the light through the proximal surface to form an image of thestructure inside the eye, wherein the proximal surface is convex along afirst direction to provide magnification along a first direction of theimage, and wherein the proximal surface is concave along a seconddirection to provide demagnification along a second direction of theimage; a handle coupled to the gonioscopic optical element; and aflexible eye engagement feature removably attachable to the gonioscopicoptical element, the eye engagement feature configured to engage betweenthe eye and an anatomical structure adjacent the eye to support thegonioscope.
 25. The gonioscope of claim 24, wherein the second directionis orthogonal to the first direction.